Hyperchloremia Is Associated With Acute Kidney Injury in Patients With Subarachnoid Hemorrhage

Critical Care Medicine
Ofer SadanOwen B Samuels

Abstract

To assess the prevalence of acute kidney injury in patients with subarachnoid hemorrhage patients. Retrospective analysis of all subarachnoid hemorrhage admissions. Neurocritical care unit. All patients with a diagnosis of subarachnoid hemorrhage between 2009 and 2014. None. Of 1,267 patients included in this cohort, 16.7% developed acute kidney injury, as defined by Kidney Disease Improving Global Outcome criteria (changes in creatinine only). Compared to patients without acute kidney injury, patients with acute kidney injury had a higher prevalence of diabetes mellitus (21.2% vs 9.8%; p < 0.001) and hypertension (70.3% vs 50.5%; p < 0.001) and presented with higher admission creatinine concentrations (1.21 ± 0.09 vs 0.81 ± 0.01 mg/dL [mean ± SD], respectively; p < 0.001). Patients with acute kidney injury also had higher mean serum chloride and sodium concentrations during their ICU stay (113.4 ± 0.6 vs 107.1 ± 0.2 mmol/L and 143.3 ± 0.4 vs 138.8 ± 0.1 mmol/L, respectively; p < 0.001 for both), but similar chloride exposure. The mortality rate was also significantly higher in patients with acute kidney injury (28.3% vs 6.1% in the non-acute kidney injury group [p < 0.001]). Logistic regression analysis revealed that only male...Continue Reading

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Citations

Sep 16, 2017·Critical Care Medicine·Ofer SadanOwen B Samuels
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