Hyperchloremic metabolic acidosis due to deferasirox in a patient with beta thalassemia major

The Annals of Pharmacotherapy
Nikolaos PapadopoulosAthanasios Kikilas

Abstract

To report a case of hyperchloremic metabolic acidosis in a patient with beta thalassemia major secondary to treatment with deferasirox due to iron overload. A 58-year-old white female with beta thalassemia major was admitted with fever, fatigue, abnormal liver function test results, and hyperchloremic metabolic acidosis (lactate dehydrogenase 494 U/L, aspartate aminotransferase 167 U/L, alanine aminotransferase 250 U/L, gamma-glutamyl transferase 102 U/L, total bilirubin 3.79 mg/dL, direct bilrubin 2.37, potassium 3.3 mEq/L, PO(2) 81.4 mm Hg, PCO(2) 29.4 mm Hg, HCO(3) 16 mEq/L, pH 7.35, chloride 116 mEq/L, anion gap 7.5 mEq/L). Twenty-five days before admission the patient decided to discontinue treatment with deferoxamine for chronic iron overload and continue treatment with oral deferasirox 1500 mg/day. Despite extended clinical and laboratory examination, no obvious cause of fever, hepatitis, or hyperchloremic metabolic acidosis was revealed. Diagnosis was compatible with tubular dysfunction, drug-induced hepatitis, and hypersensitivity reaction due to deferasirox. All pathological findings were fully reversible and our patient had an excellent outcome. The presence of tubular dysfunction should be considered in any patient ...Continue Reading

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Citations

Jul 23, 2014·Nature Reviews. Nephrology·Juan Daniel Díaz-GarcíaAlberto Ortiz
Apr 25, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Laurence DubourgPierre Cochat
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Methods Mentioned

BETA
X-ray

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