PMID: 3766045Sep 1, 1986Paper

Hypercholesterolaemia, hypotriacylglycerolaemia and increased lipoprotein lipase activity following orchidectomy in rats

Acta Endocrinologica
A HaugE Eilertsen

Abstract

Plasma lipoproteins, faecal cholesterol excretion, and activities of lecithin: cholesterol acyltransferase (LCAT) hepatic lipase (HL), and lipoprotein lipase (LPL) were determined in castrated rats, in rats treated with testosterone propionate after castration, and in sham-operated controls. Compared to control rats, whole-plasma total cholesterol (TC) rose, and triacylglycerols (TG) fell in castrated rats, but were normalized by androgen substitution. VLDL components tended to be reduced, whereas HDL2 components rose following castration. In general, testosterone substitution normalized the alterations induced by castration. Adipose tissue LPL was higher in castrated rats than in control rats, whereas activities of HL and LCAT were not significantly affected by the treatments. Hepatic cholesterol concentration, and faecal excretion of cholesterol and bile acids were not significantly altered by the treatments. Considering all 3 groups together, there was a significant positive correlation between the concentration of plasma cholesterol and cholesterol in liver, between plasma HDL2-cholesteryl esters and hepatic cholesterol, and also between HL and faecal cholesterol excretion. The results suggest that short term castration of ...Continue Reading

Citations

Sep 28, 2010·International Journal of Epidemiology·Judith S BrandYvonne T van der Schouw
Jul 30, 2011·The Urologic Clinics of North America·Keith R Solomon, Michael R Freeman
Apr 5, 2013·Journal of Medical Primatology·P NagarajanS S Majumdar
Feb 22, 2014·European Journal of Pharmacology·Gang HuangYinghao Sun
Mar 1, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B ChristoffersenV Golozoubova
Oct 2, 2004·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·J S Mayes, G H Watson
Aug 2, 2011·The British Journal of Nutrition·Satoru MakinoKiyoshi Ebihara

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