PMID: 7545522Aug 1, 1995Paper

Hypercholesterolemia and endothelial dysfunction

Current Opinion in Lipidology
P D HenryC H Chen

Abstract

Endothelial cells respond to hemodynamic forces with the expression of different phenotypes with disparate functional properties. At arterial bends and flow dividers, cells are relatively deprived of fluid-shear-stress-induced cell differentiation and exhibit phenotypes with increased mitotic rate, decreased intercellular contact, increased permeability for macromolecules, and the expression of molecules favoring constriction, adhesion, and thrombosis. Arterial sites covered by such cells are vulnerable to the atherogenic effects of hypercholesterolemia. A hallmark of endothelial cells exposed to hypercholesterolemia is a reduced capacity to release endothelium-derived relaxing factor. Pharmacological interventions that suppress or stimulate nitric oxide production appear to enhance or reduce the atherogenic effects of hypercholesterolemia.

Citations

Aug 26, 1998·Atherosclerosis·M BucayP D Henry
Dec 9, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M TurpeinenM Mutanen
Oct 10, 1998·European Journal of Clinical Investigation·I SeljeflotI Hjermann
Jul 20, 2007·Hypertension·Alejandro R ChadeLilach O Lerman
Jun 15, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jibin LinMark W Feinberg
Dec 17, 2010·World Journal of Cardiology·Flora AffusoSerafino Fazio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.