PMID: 200815Nov 1, 1977

Hypercholesterolemia and triglyceride secretion rates in monkeys fed different dietary fats

Lipids
R J NicolosiM G Herrera

Abstract

The influence of hypercholesterolemia on the triglyceride secretion rate was studied in both squirrel and cebus monkeys fed coconut oil, corn oil, or safflower oil. The triglyceride secretion rate (TGSR) was determined in vivo following the administration of Triton WR1339, which blocks the clearance of very low density lipoprotein (VLDL). Thus, the increase observed in circulating triglyceride after Triton administration presumably reflecte hepatic triglyceride (VLDL) secretion in the fasted state. The VLDL-TGSR was lowest in hypercholesterolemic monkeys and highest in those fed unsaturated fat diets and having a low serum cholesterol. In all instances, TGSR was inversely correlated with the plasma cholesterol concentration. While a definitive explanation for these observations must await further investigation, the possibility that circulating low density lipoprotein (LDL) acts to feed back on VLDL secretion is discussed. The decreased TGSR associated with the diet-induced cholesterolemia also implies clearance of VLDL is impaired under these conditions.

References

Jul 22, 1975·Biochimica Et Biophysica Acta·O W PortmanM Alexander
Mar 31, 1976·European Journal of Clinical Investigation·G SigurdssonB Lewis
Jun 22, 1976·Biochimica Et Biophysica Acta·D PetitR Infante
Nov 1, 1976·Metabolism: Clinical and Experimental·S M Grundy, H Y Mok
Dec 1, 1976·Experimental and Molecular Pathology·J E CoreyK C Hayes
Feb 1, 1974·The Journal of Nutrition·R H FiserW R Beisel
Dec 20, 1973·Biochimica Et Biophysica Acta·S EisenbergF T Lindgren
Apr 1, 1961·The Journal of Experimental Medicine·A SCANU, P ORIENTE

Citations

Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K C HayesMark C Robbins
Apr 26, 2002·Journal of Animal Physiology and Animal Nutrition·J M Hallebeek, A C Beynen

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