Hypercholesterolemia blunts the oxidative stress elicited by hypertension in venules through angiotensin II type-2 receptors

Microvascular Research
Alper YildirimD Neil Granger

Abstract

Hypertension and hypercholesterolemia elicit inflammatory and thrombogenic responses in the microvasculature. However, little is known about whether and how risk factor combinations alter microvascular function. We examined how the actions of HTN+HCh on the microvasculature differ from the responses elicited by either risk factor alone. Intravital microscopy was used to monitor the adhesion and emigration of leukocytes and dihydrorhodamine oxidation in cremaster muscle venules of wild type mice that were infused with angiotensin II for 2 weeks (HTN), placed on a high cholesterol diet (HCD), or both. Either HTN or HCh alone enhanced the production of reactive oxygen species and promoted the recruitment of leukocytes in venules. However, the combination of HTN and HCh produced changes in ROS production and leukocyte recruitment that were greatly attenuated compared to HTN alone. The inhibitory effects of HCh on the AngII mediated responses were also observed in genetically-induced HCh (ApoE-deficient mice). Treating HCh+HTN mice with an antagonist to AT2r reversed the HCh-dependent protection against oxidative stress and inflammation during HTN. These findings indicate that HCh blunts the oxidative stress and inflammatory cell re...Continue Reading

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Citations

Jul 15, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Shahdat HossainHussain Shahjalal
Nov 20, 2020·Clinical Science·U Muscha Steckelings, Colin Sumners
Mar 2, 2021·Gerontology & Geriatric Medicine·Yihe Wang, Gary S Newsome

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