Hypercholesterolemia impairs transduction of vasodilator signals derived from ischemic myocardium: myocardium-microvessel cross-talk

Arteriosclerosis, Thrombosis, and Vascular Biology
Kouichi SatoKunio Shirato

Abstract

Coronary microvessels are functionally coupled to the myocardial metabolic state. In hypercholesterolemia, the coronary vascular dysfunction extends to microvascular levels. We hypothesized that the vasodilator signal transduction from ischemic heart is impaired in the coronary microvascular wall of hypercholesterolemia. Rabbits were fed with normal chow (control group) or 2% high-cholesterol diet (hypercholesterolemia group) for 8 weeks. Coronary microvessels isolated from rabbit hearts were pressurized and gently placed on a beating canine heart. Myocardial ischemia was produced in the beating heart and the diameter of the isolated microvessel was observed using an intravital microscope with a floating objective. In control group, the isolated microvessels significantly dilated 2 minutes after the onset of ischemia, and a plateau was observed at 10 minutes. In contrast, the microvessels from hypercholesterolemia group did not dilate during ischemia. Dihydroethidium fluorescence microscopy revealed an elevated superoxide level in the microvessels of hypercholesterolemia group. The application of tiron (free radical scavenger) significantly dilated the isolated microvessels only from hypercholesterolemic animals. We conclude th...Continue Reading

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Citations

Mar 22, 2008·Journal of Cardiovascular Pharmacology·Shigefumi FukuiHiroaki Shimokawa
Jul 2, 2015·Brazilian Journal of Biology = Revista Brasleira De Biologia·D B SilvaJ A D Garcia
Dec 1, 2007·Journal of Clinical Lipidology·Matthey T HarrisW Virgil Brown
Jul 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Satoru TakedaHiroaki Shimokawa
Mar 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Katsuaki TakahashiKunio Shirato
Jan 12, 2020·Cardiovascular Research·Oana SoropDirk J Duncker

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