Hyperchromatic crowded groups in cervical cytology--differing appearances and interpretations in conventional and ThinPrep preparations: a study from the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology.

Archives of Pathology & Laboratory Medicine
Andrew A RenshawCytopathology Resource Committee, College of American Pathologists

Abstract

The practice of gynecologic cytology requires that high-grade squamous intraepithelial lesion (HSIL) be precisely recognized. In this regard, hyperchromatic crowded groups are known to be difficult to classify in conventional gynecologic cytology, but whether this is true in ThinPrep specimens is uncertain. To assess whether hyperchromatic crowded groups of cells in challenging HSIL cases are a problem in ThinPrep preparations, and whether these groups differ in appearance from those of conventional smears. Sixteen images were taken from both conventional smears and ThinPrep slides that had a reference diagnosis of HSIL in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology, but had performed poorly on subsequent participants' reviews. These 32 representative images were of hyperchromatic crowded groups and were classified by 20 Cytopathology Resource Committee members (17 pathologists and 3 cytotechnologists), who were masked to the reference diagnosis. A consensus classification was derived using the majority opinion of the individual reviewers. Finally, 5 cytologic features were assessed for those images that were interpreted as abnormal by the consensus classification. None of ...Continue Reading

Citations

Jan 24, 2007·CytoJournal·Mamatha ChivukulaVinod B Shidham
Feb 26, 2021·American Journal of Clinical Pathology·Abha GoyalMomin T Siddiqui
Aug 2, 2006·Archives of Pathology & Laboratory Medicine·Andrew A RenshawUNKNOWN Cytopathology Resource Committee, College of American Pathologists
Jan 8, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·K DentonM S Desai
Nov 2, 2021·American Journal of Clinical Pathology·Gabrielle E BaileyErika F Rodriguez

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