Abstract
Thirty-two children with solid tumors (lymphangioma, fibrosarcoma, hepatocarcinoma, osteogenic sarcoma, rhabdomyosarcoma, lymphosarcoma, mesenchymoma, hepatoma, Ewing's sarcoma, reticulum cell sarcoma, neuroblastoma, Hodgkin's disease, and brain tumors) were studied for alterations in coagulation by means of platelet counts, platelet aggregation, thrombelastogram, procoagulant and antigenic factor VIII, fibrin split products, and antithrombin III level. Results indicated hypercoagulability as shown by abnormally short thrombelastograms and elevated factor VIII levels and platelet counts in approximately one-half of the group. With the exception of increased fibrin split products in a third of the patients, little laboratory or clinical evidence for disseminated intravascular coagulation was seen. Hypercoagulability, as noted in adult carcinoma patients, can also occur in childhood sarcoma patients.
References
Apr 1, 1974·Cancer·D M Komp
May 1, 1973·Cancer·S D Peck, C W Reiquam
Jul 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·C MerskeyA J Johnson
Sep 1, 1967·Cancer·S P MillerL Zuckerman
Jan 1, 1959·British Journal of Haematology·J G POOL, J ROBINSON
Citations
Aug 23, 2001·Thrombosis Research·F R Rickles, A Falanga
Feb 19, 2000·Thrombosis Research·G A KalweitP Hellstern
Sep 18, 2002·Cancer Treatment Reviews·Agnes Y Lee
Mar 22, 2001·Journal of Clinical Anesthesia·E G PivalizzaD C Abramson
Oct 31, 2003·Critical Reviews in Oncology/hematology·Mario MandalàSandro Barni
Jul 19, 2002·Seminars in Hematology·Susan I O'Shea, Thomas L Ortel
Feb 16, 2011·Cancer Cell International·Mario MenschikowskiGabriele Siegert
Oct 1, 2009·Surgery·Jeffry L KashukJeffrey L Johnson
Dec 21, 2006·Anesthesia and Analgesia·Vance G NielsenGarry Powell
Sep 28, 2007·Paediatric Anaesthesia·Mairead HeaneyBrendan O'Hare
Oct 1, 1995·Journal of Chemotherapy·S GözdasogluA O Cavdar
Oct 5, 2019·Journal of Clinical Medicine·Valli De ReMaurizio Mascarin
May 28, 2005·Anesthesia and Analgesia·Douglas J McCrathElliott Bennett-Guerrero
Mar 24, 2020·Pediatric Hematology and Oncology·Christine KongstadAnne-Mette Hvas
May 26, 2005·Archives of Pathology & Laboratory Medicine·Donald L YeeJun Teruya