PMID: 1202173Dec 1, 1975Paper

Hypercoagulability in childhood cancer

Journal of Pediatric Surgery
W E Hathaway, T Hays

Abstract

Thirty-two children with solid tumors (lymphangioma, fibrosarcoma, hepatocarcinoma, osteogenic sarcoma, rhabdomyosarcoma, lymphosarcoma, mesenchymoma, hepatoma, Ewing's sarcoma, reticulum cell sarcoma, neuroblastoma, Hodgkin's disease, and brain tumors) were studied for alterations in coagulation by means of platelet counts, platelet aggregation, thrombelastogram, procoagulant and antigenic factor VIII, fibrin split products, and antithrombin III level. Results indicated hypercoagulability as shown by abnormally short thrombelastograms and elevated factor VIII levels and platelet counts in approximately one-half of the group. With the exception of increased fibrin split products in a third of the patients, little laboratory or clinical evidence for disseminated intravascular coagulation was seen. Hypercoagulability, as noted in adult carcinoma patients, can also occur in childhood sarcoma patients.

References

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Citations

Aug 23, 2001·Thrombosis Research·F R Rickles, A Falanga
Sep 18, 2002·Cancer Treatment Reviews·Agnes Y Lee
Mar 22, 2001·Journal of Clinical Anesthesia·E G PivalizzaD C Abramson
Oct 31, 2003·Critical Reviews in Oncology/hematology·Mario MandalàSandro Barni
Jul 19, 2002·Seminars in Hematology·Susan I O'Shea, Thomas L Ortel
Feb 16, 2011·Cancer Cell International·Mario MenschikowskiGabriele Siegert
Dec 21, 2006·Anesthesia and Analgesia·Vance G NielsenGarry Powell
Sep 28, 2007·Paediatric Anaesthesia·Mairead HeaneyBrendan O'Hare
Oct 5, 2019·Journal of Clinical Medicine·Valli De ReMaurizio Mascarin
May 28, 2005·Anesthesia and Analgesia·Douglas J McCrathElliott Bennett-Guerrero
Mar 24, 2020·Pediatric Hematology and Oncology·Christine KongstadAnne-Mette Hvas
May 26, 2005·Archives of Pathology & Laboratory Medicine·Donald L YeeJun Teruya

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