Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay.

Journal of Thrombosis and Thrombolysis
A TripodiP M Mannucci

Abstract

Diabetes is a risk factor for the development of atherothrombosis and venous thromboembolism (VTE). We investigated whether plasma from patients with type 2 diabetes has an imbalance of pro- versus anti-coagulation resulting in hypercoagulability despite normal conventional coagulation tests. We analyzed blood samples from 60 patients with type 2 diabetes and 60 gender- and age-matched healthy subjects (controls) for the levels of pro- and anti-coagulant factors, for thrombin generation and for the numbers of cell-derived circulating microparticles bearing such pro-coagulant triggers as tissue factor and negatively charged phospholipids. The levels of pro- or anti-coagulants as measured with conventional coagulation tests or single factor measurements were similar to those of the control population. In contrast, the median (range) of the height of the thrombin peak (taken as an index of thrombin generation) was higher in patients [205 nM (126-352)] than controls [151 nM (41-289)], P < 0.001. The median numbers of circulating microparticles were higher for patients [5,041/μl (1,821-13,132)] than for controls [1,753/μl (554-13,308)], P < 0.001 and their values were correlated with the height of the thrombin peak (ρ = 0.66, P < 0....Continue Reading

References

May 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·A CerielloD Giugliano
Jul 11, 2003·Pathophysiology of Haemostasis and Thrombosis·H Coenraad HemkerSuzette Béguin
Mar 10, 2004·International Journal of Hematology·Björn Dahlbäck
Oct 1, 2004·Journal of Thrombosis and Haemostasis : JTH·W JyR P Hebbel
Mar 22, 2005·Diabetologia·V PetrauskieneJ W Eriksson
Dec 24, 2005·Journal of Thrombosis and Haemostasis : JTH·D W SommeijerH ten Cate
Jul 27, 2006·JAMA : the Journal of the American Medical Association·Gregor HronPaul A Kyrle
Dec 8, 2006·Annals of the New York Academy of Sciences·Ernest AdeghateEarl Dunn
Dec 15, 2006·Journal of Thrombosis and Haemostasis : JTH·D L SaulsM Hoffman
Mar 6, 2007·Thrombosis and Haemostasis·Elena I SinauridzeFazoil I Ataullakhanov
Aug 19, 2007·Journal of Internal Medicine·P Prandoni
Dec 19, 2007·Circulation·Walter AgenoPieter W Kamphuisen
Jan 25, 2008·Thrombosis and Haemostasis·Francis CouturaudUNKNOWN Groupe d'Etude de la Thrombose de Bretagne Occidentale (G.E.T.B.O)
Apr 12, 2008·Haematologica·Armando TripodiPier Mannuccio Mannucci
Mar 12, 2009·Thrombosis and Haemostasis·Laurent BurnierAnne Angelillo-Scherrer
Apr 15, 2009·The American Journal of the Medical Sciences·Paul D SteinAbdo Y Yaekoub
Jun 18, 2009·Current Diabetes Reviews·Shosaku Nomura
Jun 23, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·John A HeitL Joseph Melton
Jul 17, 2009·Current Opinion in Hematology·Pavel Davizon, José A López
Aug 8, 2009·British Journal of Haematology·Armando TripodiPier M Mannucci
Aug 27, 2009·Gastroenterology·Armando TripodiPier Mannuccio Mannucci
Sep 29, 2009·European Journal of Internal Medicine·Massimo Franchini, Pier Mannuccio Mannucci

❮ Previous
Next ❯

Citations

Nov 19, 2011·Veterinary Clinical Pathology·Lara J RoseChristian Bédard
Jun 30, 2011·Thrombosis and Haemostasis·Gala TsimermanAnat Aharon
Nov 23, 2011·Anesthesia and Analgesia·Alisa S WolbergKellie R Machlus
Feb 20, 2016·Biochemical and Biophysical Research Communications·Nicoleta AlexandruAdriana Georgescu
Jan 23, 2013·Journal of Drug Targeting·Jie ZhengYu Liu
Feb 15, 2016·Journal of Diabetes and Its Complications·Diana Hedevang ChristensenHenrik Toft Sørensen
Mar 15, 2015·Thrombosis Research·Smith Giri, Lisa K Jennings
Nov 15, 2011·Thrombosis Research·Hugo Ten Cate
Oct 1, 2011·European Journal of Clinical Investigation·Leyla AyGuntram Schernthaner
May 9, 2012·The American Journal of Medicine·Gregory PiazzaFrederick A Spencer
Mar 25, 2014·Journal of Hepatology·Armando TripodiSilvia Fargion
Apr 3, 2014·Thrombosis Research·Armando TripodiFlora Peyvandi
Jan 28, 2016·Journal of Thrombosis and Haemostasis : JTH·D SegnaN Rodondi
Mar 6, 2012·Vascular Pharmacology·Voahanginirina Randriamboavonjy, Ingrid Fleming
Jan 31, 2015·Thrombosis Journal·Elena N Lipets, Fazoil I Ataullakhanov
Oct 5, 2013·Blood·Fahumiya Samad, Wolfram Ruf
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Jun 18, 2016·Biosensors & Bioelectronics·Suzuyo InoueEmi Tamechika
Jul 6, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Javier de Miguel-DíezAna López de Andrés
Jul 30, 2016·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Elisabeth Maurer-SpurejKate Chipperfield
Feb 22, 2012·Journal of Cardiovascular Medicine·Gianluca TibertiFelice Achilli
Mar 21, 2017·Expert Review of Medical Devices·Tetsuo SasanoSatomi Hamada
May 10, 2017·Journal of Vascular Research·Yan LiuManuela Martins-Green
Jan 30, 2015·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hua WangWeizhong Jin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.