Hypercoagulable state and methylenetetrahydrofolate reductase (MTHFR) C677T mutation in patients with beta-thalassemia major in Kuwait

Acta Haematologica
Nada Y MustafaOlusegun Mojiminiyi

Abstract

Patients with thalassemia major often present with a hypercoagulable state, the pathogenesis of which is still not understood. This study evaluates the risk factors for hypercoagulability in 50 beta-thalassemia major patients and 50 healthy controls. Fasting total homocysteine, protein C (PC), protein S (PS), antithrombin (AT), activated protein C resistance (APCR) and lupus anticoagulant (LA) were assessed. MTHFR C677T mutation was determined. Significant reductions in PC, PS and AT were noted in patients. Only 4% of the patients had hyperhomocysteinemia. Thirty-two percent of the patients were heterozygous and 4% were homozygous for MTHFR C677T mutation. The natural coagulation inhibitors PC, PS and AT were significantly reduced in patients with beta-thalassemia major and were thus important risk factors for the hypercoagulable state, but hyperhomocysteinemia and MTHFR mutation do not seem to be significant risk factors for thromboembolic events.

Citations

May 7, 2013·Surgical Neurology International·Ha Son NguyenLaurie L Ackerman
Aug 13, 2015·International Journal of Environmental Research and Public Health·Sameer Al ZenkiAmani Al Othman
Oct 22, 2016·Journal of Pediatric Hematology/oncology·Mozhgan HashemiehKourosh Sheibani
Mar 24, 2016·Annals of the New York Academy of Sciences·Dustin R Fraidenburg, Roberto F Machado
Aug 19, 2021·Blood Reviews·Georges El HasbaniAli T Taher

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