Hypercoagulable state associated with kidney-pancreas transplantation. Thromboelastogram-directed anti-coagulation and implications for future therapy

Clinical Transplantation
George W BurkeJoshua Miller

Abstract

The clinical consequences of type 1 diabetes mellitus (IDDM) include diabetic triopathy: retinopathy, nephropathy, and neuropathy, as well as microangiopathy, accelerated atherosclerotic disease, and hypercoagulability. The etiology of the hypercoagulability is multifactorial, involving various clotting factors or pathways (for example platelets, fibrinogen, individual components of the clotting system and/or fibrinolysis in different studies). The development of end-stage renal disease (ESRD), with the uremia-related platelet effect has the potential to protect from the existing hypercoagulable state. This has important implications for surgery, particularly simultaneous pancreas-kidney (SPK) transplantation, where the pancreas has historically been prone to thrombosis. This has led us to perform intra-operative thromboelastograms (TEG's) to evaluate the patient's current coagulation status. A TEG was performed in 85 SPK recipients along with a control group of 54 non-diabetic kidney transplant (KT) recipients. For each of the 4 TEG coagulation parameters, the SPK recipients were significantly more hypercoagulable than the non-diabetic KT recipients. The use of intra-operative heparin is based on the degree of hypercoagulabili...Continue Reading

Associated Clinical Trials

Sep 21, 2007·George W. Burke, George W. Burke

References

Mar 15, 1987·Thrombosis Research·D S HollowayL F Mockros
Jan 1, 1968·Acta Haematologica·J G San Miguel, R Castillo
Jan 1, 1993·Progress in Lipid Research·G J Miller
Aug 1, 1997·Journal of the American College of Surgeons·R W GruessnerA C Gruessner
Sep 1, 1997·Journal of Clinical Anesthesia·E G PivalizzaA Harvey
Nov 14, 1997·Annals of Surgery·R W GruessnerD E Sutherland
Sep 22, 1998·Annals of Surgery·H W SollingerJ D Pirsch
Mar 10, 2001·Cell·C K Glass, J L Witztum
Jul 31, 2001·Transplantation·J R ChapmanR D Allen
Mar 6, 2002·Circulation·Peter LibbyAttilio Maseri
Mar 13, 2002·Circulation·Johann W AuerBernd Eber
Aug 15, 2002·Transplantation Proceedings·George W BurkeJ Miller

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Citations

Feb 21, 2013·Surgery Today·Yasuhiro OkabeMasao Tanaka
Sep 10, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Neal BangaJohn Taylor
Jun 24, 2005·Transplantation·Axel AndresThierry Berney
Jul 10, 2010·Transplantation·Anand S R MuthusamyPeter J Friend
Jun 26, 2012·Transplantation·Mathieu PageBernard Allaouchiche
May 29, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Shaneel R Patel, Nadey Hakim
Jan 15, 2013·Journal of the American College of Surgeons·Chad M ThorsonKenneth G Proctor
Feb 8, 2011·Journal of Clinical Anesthesia·Kyota Fukazawa, Ernesto A Pretto
Apr 21, 2010·Best Practice & Research. Clinical Anaesthesiology·Vance G Nielsen, Lars M Asmis
Sep 9, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Arturo PradoFrancisco Parada
Nov 10, 2015·Current Diabetes Reports·George W BurkeAlberto Pugliese
Mar 24, 2005·Clinical and Laboratory Haematology·R J Luddington
Jun 20, 2009·Clinical Transplantation·Peter SchenkerRichard Viebahn
Jul 15, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A S R MuthusamyP J Friend
Aug 30, 2008·The Mount Sinai Journal of Medicine, New York·Susan M Lerner
Jul 25, 2007·Clinical Transplantation·Anil VaidyaP J Friend
Oct 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J SageshimaG W Burke
Jan 15, 2014·Clinical Transplantation·Jeffrey RogersRobert J Stratta
May 2, 2014·Clinical Transplantation·Junichiro SageshimaGeorge W Burke
May 28, 2013·Orvosi hetilap·Károly Kalmár NagyRóbert Langer
Feb 11, 2016·Transplantation·Jose Alejandro Lugo-BaruquiGeorge W Burke
Jul 19, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A HakeemK Saeb-Parsy
Sep 22, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Banu Pinar Sarer YürekliAlper Gürlek
Jun 4, 2019·Clinical Transplantation·Yehuda RavehRamona Nicolau-Raducu
Apr 9, 2016·Current Opinion in Organ Transplantation·Jerome M Laurence, Mark S Cattral
May 25, 2016·Plastic and Reconstructive Surgery·Casey J AllenKenneth G Proctor
Dec 10, 2019·Journal of Orthopaedic Trauma·Wesley BrownMara Schenker
Oct 28, 2019·Transplantation·Benedict L PhillipsMartin Drage
Oct 28, 2017·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Cigdem BinayOlga Meltem Akay
Dec 14, 2018·Transplant International : Official Journal of the European Society for Organ Transplantation·Wouter H KoppAndries E Braat
Jul 15, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J W HarbellP Stock
Aug 28, 2020·World Journal of Transplantation·Jeevan Prakash GopalAnand Sr Muthusamy
Jun 3, 2008·Molecular Biology Reports·Elias KfouryRami Mahfouz
Nov 23, 2020·Clinical Transplantation·Matthew H V ByrneColin H Wilson
Mar 19, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Christophe MassetDiego Cantarovich
May 1, 2021·Journal of Clinical Medicine·Madhivanan Elango, Vassilios Papalois
Jul 11, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ugo BoggiThierry Berney

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