PMID: 8597440Dec 29, 1995Paper

Hypercortisolism and obesity

Annals of the New York Academy of Sciences
P M Peeke, George P Chrousos

Abstract

Obesity is a multifactorial heterogenous condition. The location of excess fat on the body determines the risk of morbidity and mortality for significant disease. Visceral, or intraabdominal, fat is the fat depot most highly associated with illness and death from cardiocerebrovascular disease and diabetes. Visceral fat is also associated with a quartet of metabolic disturbances. Referred to as the metabolic syndrome, these abnormalities include hypertension, hyperlipidemia, hyperinsulinemia, and insulin resistance. The metabolic syndrome is also present in Cushing's syndrome, which is characterized by primary hypercortisolism as well as profound visceral adiposity and obesity. The interrelationship between hyperactivation or hypersensitivity of the stress axis and disease can be elucidated by an understanding of the effect of excess glucocorticoids upon energy storage and metabolism. The complex interactions of the stress axis upon the growth and reproductive axes, as well as upon the adipose tissue, suggest that chronic stress, whether psychological and/or physical, exerts an intense effect upon body composition, which, in turn, significantly affects the longevity and survival of the organism.

References

Jun 1, 1975·Metabolism: Clinical and Experimental·M KtotkiewskiU Smith
Nov 1, 1992·Metabolism: Clinical and Experimental·P MårinP Björntorp
Dec 1, 1991·Diabetes Care·P Björntorp
Jun 1, 1991·The Journal of Clinical Endocrinology and Metabolism·G S Wand, A S Dobs
Jan 1, 1990·The Journal of Clinical Endocrinology and Metabolism·F F CasanuevaC Dieguez
Apr 1, 1990·Clinical Endocrinology·S MalozowskiF Cassorla
Nov 1, 1990·The American Journal of Clinical Nutrition·C BouchardV S Hubbard
Mar 29, 1990·The New England Journal of Medicine·J E MansonC H Hennekens
Aug 18, 1988·The New England Journal of Medicine·P W GoldG P Chrousos
Sep 1, 1988·Diabetes/metabolism Reviews·P Björntorp
Jan 1, 1988·Advances in Experimental Medicine and Biology·D RabinG P Chrousos
Aug 11, 1988·The New England Journal of Medicine·P W GoldG P Chrousos
May 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·C A ShivelyK W Weingand
Nov 1, 1974·Metabolism: Clinical and Experimental·P Björntorp
Oct 1, 1971·Metabolism: Clinical and Experimental·P BjörntorpL Wilhelmsen
Sep 1, 1971·European Journal of Clinical Investigation·P BjörntorpB Larsson
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D J EvansA H Kissebah
Sep 1, 1983·The Journal of Clinical Investigation·M KrotkiewskiU Smith
Jan 1, 1984·Psychopharmacology·R J WestB Kadam
Feb 1, 1982·The Journal of Clinical Endocrinology and Metabolism·A H KissebahP W Adams
Jul 1, 1994·Baillière's Clinical Endocrinology and Metabolism·P G Kopelman
Dec 31, 1964·The New England Journal of Medicine·A G FRANTZ, M T RABKIN
May 1, 1993·Obesity Research·P Björntorp

❮ Previous
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Citations

Jul 4, 2003·The Journal of Clinical Investigation·Hiroaki MasuzakiJeffrey S Flier
Mar 22, 2006·Expert Opinion on Therapeutic Targets·Guillaume J Hervieu
Feb 22, 2007·The Journal of Biological Chemistry·Jaime KimMatthew J Brady
Nov 26, 2008·The Journal of Biological Chemistry·Linda J MullinsChristopher J Kenyon
Mar 27, 2009·Metabolic Syndrome and Related Disorders·Kevin D LaugeroDavid G Parkes
Jul 9, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Mousumi BoseBlandine Laferrère
Apr 16, 2010·Stress : the International Journal on the Biology of Stress·M WadiwallaJ C Pruessner
Sep 10, 2010·American Journal of Physiology. Renal Physiology·Camila HirotsuMonica Levy Andersen
Apr 3, 2012·Journal of Materials Science. Materials in Medicine·Flávia Carmo Horta PintoGisele Rodrigues Da Silva
Apr 23, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Dan S SharpDiane B Miller
Mar 13, 2014·Nature Communications·Mirjam GeibelLiliana Minichiello
Dec 27, 2018·Journal of Pineal Research·María Elisa MercauCora Beatriz Cymeryng
Jan 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J H ThakoreR Reznek
Mar 31, 2006·Obesity·Mark DanielMarci K Campbell
May 1, 2007·Clinical Endocrinology·Thomas G TravisonJohn B McKinlay
Apr 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan E CampbellMichael C Riddell
Nov 11, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Sainsbury, L Zhang
Jul 16, 2010·Calcified Tissue International·Han Seok ChoiSung-Kil Lim
Oct 23, 2014·European Journal of Endocrinology·Petros ConstantinopoulosVenetsana Kyriazopoulou
Nov 20, 2016·Journal of Behavioral Medicine·Jennifer HubertySara L Kornfield
Jul 14, 2017·Endocrine·Michael DreyRalf Schmidmaier
Mar 19, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Elzbieta PaszynskaMonika Dmitrzak-Weglarz
Jul 9, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·S ActonJ M Ordovas
Feb 1, 2007·International Journal of Clinical Practice·E A Francischetti, V A Genelhu
Sep 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Alli M Nuotio-AntarAlyssa H Hasty
Jun 30, 2010·Journal of Enzyme Inhibition and Medicinal Chemistry·Rajeev KharbMohammed Shahar Yar
Mar 4, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L HuneaultA Tremblay
Jan 29, 2014·Endocrinology·Gretha J BoersmaKellie L Tamashiro
Jan 11, 2013·Physiological Reviews·André Tchernof, Jean-Pierre Després
Mar 27, 1999·Journal of Women's Health·S C Finn
May 22, 2002·Endocrinology·Christoph KellendonkEckhart Simon
Jun 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M A MagiakouG P Chrousos

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