Hyperdopaminergic behavioral spectrum in Parkinson's disease: A review

Revue neurologique
Matthieu BéreauP Krack

Abstract

Impulse control disorders (ICDs) and other related behaviors, such as punding and dopamine dysregulation syndrome, are frequent yet underrecognized non-motor complications of dopamine replacement therapy (DRT) in Parkinson's disease (PD); they can also have a major negative impact on quality of life. They result from complex interactions between a given individual's predispositions, non-physiological dopaminergic stimulation and PD pathology. Also, sensitization of the mesocorticolimbic pathway, reflected by the psychotropic effects of dopaminergic treatment, plays a crucial role in the emergence of these addictive behaviors. While early detection of changes in behavior, less use of dopamine agonists (DA) that have a relative selectivity for mesocorticolimbic dopamine receptors, and fractionation of levodopa dosages to avoid non-physiological pulsatile stimulation of dopamine receptors are key strategies in the management of this hyperdopaminergic behavioral spectrum, other complementary approaches are also addressed in this review.

Citations

Apr 3, 2019·Nature Reviews. Neurology·Walid BouthourPaul Krack
Apr 9, 2019·Current Treatment Options in Neurology·Maria Livia FantiniAna Marques
Sep 16, 2020·L'Encéphale·M A GorsaneX Laqueille
Mar 20, 2019·Neurological Research and Practice·Matthieu BéreauThomas F Münte
Aug 17, 2021·Parkinsonism & Related Disorders·Michele FusaroliElisabetta Poluzzi
Jul 9, 2021·Annals of Neurology·Daniel WeissGünther Deuschl
Nov 30, 2021·Fortschritte der Neurologie-Psychiatrie·Daniel WeissHeinz Reichmann

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