PMID: 9540952Apr 16, 1998Paper

Hyperemesis gravidarum associated with Helicobacter pylori seropositivity

Obstetrics and Gynecology
P FrigoA M Hirschl

Abstract

To test the hypothesis that infection with Helicobacter pylori is associated with hyperemesis gravidarum. From January 1995 to November 1996 we enrolled 105 patients with hyperemesis gravidarum in a prospective study. The Helicobacter serum Immunoglobulin (Ig) G concentrations in these patients were compared with those in asymptomatic gravidas matched for week of gestation. Positive serum IgG concentrations were found in 95 of the 105 hyperemesis patients (90.5%) compared with 60 of 129 controls (46.5%). A chi2 test showed statistical significance (P < .001). The mean (+/-standard deviation) index percentages of the IgG titers were 74.2+/-23.6% in the hyperemesis group and 24.3+/-4.4% in the control group (P < .01, Student t test). Infection with H pylori may cause hyperemesis gravidarum.

References

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Feb 9, 2010·Archives of Gynecology and Obstetrics·Irene Sandven, Michael Abdelnoor
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