Hyperendemic dengue transmission and identification of a locally evolved DENV-3 lineage, Papua New Guinea 2007-2010

PLoS Neglected Tropical Diseases
Dagwin Luang-SuarkiaAllison Imrie

Abstract

Dengue is endemic in the Western Pacific and Oceania and the region reports more than 200,000 cases annually. Outbreaks of dengue and severe dengue occur regularly and movement of virus throughout the region has been reported. Disease surveillance systems, however, in many areas are not fully established and dengue incidence is underreported. Dengue epidemiology is likely least understood in Papua New Guinea (PNG), where the prototype DENV-2 strain New Guinea C was first isolated by Sabin in 1944 but where routine surveillance is not undertaken and little incidence and prevalence data is available. Serum samples from individuals with recent acute febrile illness or with non-febrile conditions collected between 2007-2010 were tested for anti-DENV neutralizing antibody. Responses were predominantly multitypic and seroprevalence increased with age, a pattern indicative of endemic dengue. DENV-1, DENV-2 and DENV-3 genomes were detected by RT-PCR within a nine-month period and in several instances, two serotypes were identified in individuals sampled within a period of 10 days. Phylogenetic analysis of whole genome sequences identified a DENV-3 Genotype 1 lineage which had evolved on the northern coast of PNG which was likely export...Continue Reading

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Apr 25, 2017·PLoS Neglected Tropical Diseases·Dagwin Luang-SuarkiaAllison Imrie

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Datasets Mentioned

BETA
KY794785-KY794790

Methods Mentioned

BETA
ELISA
Assay
PCR

Software Mentioned

Data Monkey
MACSE
Se
CLC Genomics Workbench
Al
MacClade
HyPhy
RAxML

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