Hypereosinophilic syndrome: lymphoproliferative and myeloproliferative variants

Seminars in Respiratory and Critical Care Medicine
F RoufosseE Cogan

Abstract

Idiopathic hypereosinophilic syndrome is a largely heterogeneous disorder defined as persistent, marked hypereosinophilia of unknown origin complicated by end-organ damage. Recent research in cellular and molecular biology has led to the characterization of distinct underlying hematological disorders, primitively involving cells of the myeloid or lymphoid lineage. The ability to classify many hypereosinophilic syndrome patients on the basis of pathogenesis of hypereosinophilia has radically changed therapeutic perspectives. Indeed, imatinib mesylate has become first-line therapy for patients in whom the FIP1L1-PDGFRalpha fusion gene is detected, whereas corticosteroids remain the mainstay for management of patients in whom hypereosinophilia is secondary to the overproduction of interleukin 5 by abnormal T-cells. Use of monoclonal anti-interleukin-5 antibodies in the latter group of patients has a strong rationale and could decrease cumulative corticosteroid doses and toxicity. As far as prognosis of these disease variants is concerned, hypereosinophilic syndrome patients with the FIP1L1-PDGFRalpha fusion gene may develop acute myelogenous (eosinophilic) leukemia, whereas those with clonal interleukin-5-producing T-cells have an...Continue Reading

Citations

Mar 25, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·T KleinfeldtH Ince
Feb 24, 2012·Current Allergy and Asthma Reports·Sabine Gisela PlötzJohannes Ring
Mar 18, 2008·The New England Journal of Medicine·Marc E RothenbergUNKNOWN Mepolizumab HES Study Group
Dec 6, 2008·Current Opinion in Hematology·Javed Sheikh, Peter F Weller
Apr 15, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Fred H Hsieh
Jun 23, 2010·Current Medical Research and Opinion·Lawrence B SchwartzAnish Singh
Mar 31, 2012·The Journal of Allergy and Clinical Immunology·Peter ValentGerald J Gleich
Apr 8, 2010·The Journal of Allergy and Clinical Immunology·William W BusseJean-Emmanuel Kahn
Apr 9, 2008·Leukemia Research·Caroline ThielenLaurence de Leval
Oct 27, 2007·La Revue de médecine interne·E Cogan, F Roufosse
Sep 18, 2007·Immunology and Allergy Clinics of North America·Javed Sheikh, Peter F Weller
Sep 28, 2015·Clinical Reviews in Allergy & Immunology·Wei LiaoQianjin Lu
Jan 10, 2014·Allergy, Asthma & Immunology Research·Kyung-Suk LimByung-Jae Lee
Oct 6, 2011·Current Opinion in Allergy and Clinical Immunology·Jonathan Corren
Jun 12, 2020·American Journal of Clinical Pathology·Daiva M MattisChuanyi M Lu
Feb 26, 2011·Clinical Pharmacokinetics·Deborah A SmithMisba Beerahee
Jul 29, 2020·Immunological Investigations·Reza KianiSimin Almasi
Oct 18, 2007·Current Opinion in Pulmonary Medicine·Tatjana Peros-Golubicić, Silvana Smojver-Jezek
Jul 21, 2009·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Luiz Eduardo Mendes Campos, Luiz Fernando Ferreira Pereira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Allergy and Clinical Immunology
A D KlionThe Hypereosinophilic Syndromes Working Group
Current Opinion in Immunology
Gerald J Gleich, Kristin M Leiferman
Annual Review of Medicine
F RoufosseMichel Goldman
© 2022 Meta ULC. All rights reserved