Hyperfibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardiovascular disease in patients with chronic renal failure on conservative treatment

The American Journal of the Medical Sciences
Krystyna PawlakDariusz Pawlak

Abstract

Disturbances of the fibrinolytic system and kynurenine (KYN) pathway of tryptophan (TRP) metabolism have been postulated as important factors in the pathogenesis of cardiovascular disease (CVD). However, no data are yet available on the associations between these 2 systems in relation to CVD prevalence in patients with chronic renal failure (CRF). We evaluated TRP and its metabolites, KYN, 3-hydroxykynurenine, and quinolinic acid (QA), and their relations with the parameters of the fibrinolytic system, such as tissue-type plasminogen activators and urokinase-type (uPA) plasminogen activators, plasmin-antiplasmin (PAP) complexes, plasminogen activator inhibitor-1, and Cu/Zn superoxide dismutase (Cu/Zn SOD) levels as the marker of oxidative stress in a population of 50 patients with CRF and 20 healthy controls. In addition, the relations of these parameters to CVD prevalence in patients with CRF were also determined. Compared with controls, the CRF group had significantly increased KYNs, PAP, uPA, soluble urokinase PA receptor (suPAR), plasminogen activator inhibitor-1 (all P < 0.0001), and tissue-type plasminogen activators (P < 0.01) concentrations. TRP levels were significantly lower (P < 0.0001), whereas Cu/Zn SOD levels did ...Continue Reading

References

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Citations

Mar 22, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rutger J H MaasJack F M Wetzels
Oct 15, 2013·BMC Cardiovascular Disorders·Mikkel Malby SchoosKasper Karmark Iversen
Apr 8, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yutaka HaritaMotoshi Hattori
Feb 18, 2011·Canadian Journal of Physiology and Pharmacology·Mariana Alves de Sá SiqueiraAntônio C Mendes-Ribeiro
Nov 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jonathan HoganGerald B Appel
Jun 12, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Krystyna PawlakDariusz Pawlak
Mar 5, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sanjeev SethiFernando C Fervenza
Jan 14, 2017·Critical Reviews in Clinical Laboratory Sciences·S DesmedtM M Speeckaert
Aug 2, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bharath Chelluboina, Raghu Vemuganti
Jan 19, 2021·Oxidative Medicine and Cellular Longevity·Iwona KwiatkowskaDariusz Pawlak
Oct 8, 2021·Pharmacological Reports : PR·Izabela Zakrocka, Wojciech Załuska
Dec 9, 2021·JCI Insight·Breanne H Y GibsonJonathan G Schoenecker

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