Hyperglycaemia and the risk of post-surgical adhesion

Archives of Physiology and Biochemistry
Gordon A FernsMohammad-Hassan Arjmand

Abstract

Post-surgical adhesions are a major complication leading to organ dysfunctions, pain, intestinal obstruction, and infertility. The incidence of post-surgical adhesion is really high. The factors involved in the pathogenesis of post-surgical fibrosis, are largely unknown, for example why two patients with similar abdominal operation have a different risks of adhesion severity? High secretion of pro-inflammatory cytokines and growth factors, includes tumour necrosis factor α (TNF-α), interleukin 6 (IL6), and transforming growth factor β (TGF-β) by persistent recruitment of immune cells and the inappropriate proliferated fibroblast/mesothelial cells can stimulate signalling pathways particularly TGF-β leads to the up-regulation of some pro-fibrotic genes that impair fibrinolytic activity and promote extracellular matrix (ECM) accumulation. In this review, we focus on the role of diabetes and hyperglycaemia on post-surgical fibrosis, including the molecular mechanisms affected by hyperglycaemia that cause inflammation, oxidative stress, and increase the expression of pro-fibrotic molecules.

References

Jun 4, 1977·British Medical Journal·B I Seneviratne
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H VlassaraR Bucala
Jan 1, 1988·Enzyme·E K Kruithof
Mar 1, 1987·The Journal of Pathology·Z FotevJ M Papadimitriou
Nov 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Martinez-Hernandez, P S Amenta
May 1, 1994·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D ZhuS M Mauer
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E G NabelR Derynck
Jun 1, 1996·Surgery·L HolmdahlB Risberg
Jan 1, 1997·Free Radical Biology & Medicine·G Poli, M Parola
Jul 1, 1997·Lancet·E P Feener, G L King
Jul 11, 1998·The Journal of Biological Chemistry·T L Vanden HoekP T Schumacker
Dec 28, 1999·Microbes and Infection·M H Branton, J B Kopp
Sep 27, 2000·Diseases of the Colon and Rectum·M G ColemanB J Moran
Oct 31, 2000·The Journal of Pathology·H SulaimanS E Herrick
Dec 1, 2001·Human Reproduction Update·M P Diamond, M L Freeman
Apr 12, 2002·Journal of Neurochemistry·Yuanbin LiuDavid Schubert
Jun 1, 2002·Science·Lewis C Cantley
Apr 24, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin H LiHui Y Lan
Apr 30, 2003·Diabetes Care·Katherine EspositoDario Giugliano
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Stephen S M ChungSookja K Chung
Jul 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Atul SahaiPeter F Whitington
Jul 17, 2004·Histochemistry and Cell Biology·George L King, Mary R Loeken
Nov 13, 2004·The Journal of Biological Chemistry·Ying LinPhilipp E Scherer
Jul 21, 2005·Das Gesundheitswesen·C HerderUNKNOWN KORA Study Group
Oct 20, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M C ParkerUNKNOWN Surgical and Clinical Adhesions Research (SCAR) Group
Feb 24, 2006·Toxicology and Applied Pharmacology·Anabela P Rolo, Carlos M Palmeira

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