Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise.

Nature Metabolism
Tara L MacDonaldSarah J Lessard

Abstract

Increased aerobic exercise capacity, as a result of exercise training, has important health benefits. However, some individuals are resistant to improvements in exercise capacity, probably due to undetermined genetic and environmental factors. Here, we show that exercise-induced improvements in aerobic capacity are blunted and aerobic remodelling of skeletal muscle is impaired in several animal models associated with chronic hyperglycaemia. Our data point to chronic hyperglycaemia as a potential negative regulator of aerobic adaptation, in part, via glucose-mediated modifications of the extracellular matrix, impaired vascularization and aberrant mechanical signalling in muscle. We also observe low exercise capacity and enhanced c-Jun N-terminal kinase activation in response to exercise in humans with impaired glucose tolerance. Our work indicates that current shifts in dietary and metabolic health, associated with increasing incidence of hyperglycaemia, might impair muscular and organismal adaptations to exercise training, including aerobic capacity as one of its key health outcomes.

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Citations

Jul 23, 2020·Nature Metabolism·Katja A Lamia
Sep 9, 2020·Nature Reviews. Endocrinology·Lauren Gerard Koch, Steven Loyal Britton
Aug 13, 2020·Nature Reviews. Endocrinology·Alan Morris
Jan 12, 2021·The Journal of Physiology·Robert M EdinburghJavier T Gonzalez
Oct 15, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Flavia Giolo De CarvalhoEllen Cristini de Freitas
May 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Logan K TownsendDavid C Wright
Jul 16, 2021·Medicine and Science in Sports and Exercise·David P FergusonAshley N Triplett
Jun 29, 2021·American Journal of Physiology. Endocrinology and Metabolism·Juulia H LautaojaJuha J Hulmi
Aug 17, 2021·Medicine and Science in Sports and Exercise·Heath M BurtonEdward F Coyle

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
X-ray
blood collection
biopsies
dissections
PCR

Software Mentioned

GraphPad Prism
GraphPad
CI Multi Device
ImageJ
CellProfiler
Gotime

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