Hyperglycaemia per se does not affect erythrocyte glucose-6-phosphate dehydrogenase activity in ketosis-prone diabetes

Diabetes & Metabolism
S P ChoukemJ-F Gautier

Abstract

Previously, we described patients with ketosis-prone type 2 diabetes (KPD) and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but no mutation of the G6PD gene. Our present study used two complementary approaches to test whether hyperglycaemia might inhibit G6PD activity: (1) effect of acute hyperglycaemia induced by glucose ramping; and (2) effect of chronic hyperglycaemia using correlation between G6PD activity and HbA1c levels. In the first substudy, 16 KPD patients were compared with 11 healthy, non-diabetic control subjects of the same geographical background. Erythrocyte G6PD activity and plasma glucose were assessed at baseline and every 40 min during intravenous glucose ramping that allowed maintaining hyperglycaemia for more than 3h. In the second substudy, erythrocyte G6PD activity and HbA1c levels were evaluated in 108 consecutive African patients with either type 2 diabetes or KPD, and a potential correlation sought between the two variables. The maximum plasma glucose level after 200 min of glucose perfusion was 20.9±3.7 mmol/L for patients and 10.7±2.3mmol/L for controls. There was no difference between baseline and repeated G6PD activity levels during acute hyperglycaemia in either KPD patients (P=0.94) or c...Continue Reading

References

Aug 1, 1970·Diabetologia·A G BillisS C Papastamatis
Oct 3, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·E SobngwiJ F Gautier
Jan 8, 2008·Lancet·M D Cappellini, G Fiorelli
Sep 24, 2008·Diabetes Care·Simeon-Pierre ChoukemJean-François Gautier

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Citations

May 24, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Priyathama Vellanki, Guillermo E Umpierrez
Jan 1, 2020·Journal of Diabetes and Metabolic Disorders·Parvaneh AsadiMohammad Ali Takhshid

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