PMID: 16503322Mar 1, 2006Paper

Hyperglycemia and gatifloxacin: a case report and summary of current literature

The American Journal of Geriatric Pharmacotherapy
Lauren A Beste, Tracey L Mersfelder

Abstract

Gatifloxacin is a widely used fluoroquinolone antibiotic. Several case reports have described hyperglycemia that is related to gatifloxacin use. Our goal was to report a new case of gatifloxacin-related hyperglycemia in a nondiabetic patient with acute renal dysfunction. Also summarized are data from existing case reports. A 71-year-old man with a history of coronary artery disease was admitted for saphenous vein harvest site infection, atrial fibrillation, postoperative Dressler's syndrome, and resolving acute renal failure after coronary artery bypass graft 10 days prior. His history was notable for the absence of diabetes mellitus. Four days after initiating gatifloxacin 400 mg/d for a wound infection and 3 days after an increase in serum creatinine to 2.8 mg/dL, his fasting serum glucose level was elevated to 209 mg/dL on routine laboratory evaluation. Standard dose sliding scale insulin was begun to control the patient's blood glucose, and his gatifloxacin dose was lowered to 200 mg/d due to his diminished renal function. The patient's blood glucose levels normalized rapidly after his course of gatifloxacin was completed. Thirteen cases of gatifloxacin-related hyperglycemia have been reported in the medical literature, 10 ...Continue Reading

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Citations

Feb 26, 2008·Pharmacy World & Science : PWS·Ahunna J OnyenwenyiRandy C Hatton
Jan 11, 2007·Clinical Therapeutics·Clifford Yip, Audrey J Lee
Dec 17, 2008·Biochemical Pharmacology·Hany GhalyIngo Rustenbeck
Dec 4, 2014·Primary Care Diabetes·Sarah El Ghandour, Sami T Azar
Dec 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takashi Tomita
May 20, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Seth M GarberSusan M Miller
Apr 6, 2007·Biological & Pharmaceutical Bulletin·Takashi TomitaKenji Kihira
Dec 14, 2007·Health Care Management Science·George W Pasdirtz

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