Hyperglycemia and plasma lipid levels: a prospective study of young insulin-dependent diabetic patients

The New England Journal of Medicine
J M SosenkoK H Gabbay

Abstract

We explored the relation of plasma lipid levels to the degree of blood glucose control in young, insulin-dependent diabetic patients. Levels of total plasma cholesterol and triglyceride, of their lipoprotein subfractions, and of hemoglobin A, and fasting blood glucose were measured repeatedly over a one-year period in 105 patients. Lipid levels were also measured in 74 nondiabetic siblings. Increasingly poor control of diabetes, reflected by levels of hemoglobin A1 or of fasting blood glucose, was associated with statistically significant increases in total cholesterol (P less than or equal to 0.01), total triglyceride (P less than or equal to 0.007), and lipoprotein subfractions except for high-density lipoprotein cholesterol. Diabetic patients in best control had lipid levels similar to those in their nondiabetic siblings. These data on the relation of plasma lipid levels to diabetic control lend credence to the hypothesis that poor control of blood glucose is conducive to accelerated atherosclerosis in diabetes mellitus.

References

Aug 1, 1977·Diabetologia·M F Lopes-VirellaJ A Colwell
Jun 1, 1978·Atherosclerosis·B V HowardP H Bennett
Jan 1, 1978·Clinical Endocrinology·J I MannJ D Baum
May 1, 1977·The Journal of Clinical Endocrinology and Metabolism·K H GabbayP M Gallop
Jun 1, 1975·Diabetes·A T Paz-GuevaraP White
Jan 1, 1963·Acta Paediatrica·G STERKYB PERSSON

❮ Previous
Next ❯

Citations

Feb 1, 1990·Diabetes/metabolism Reviews·F L Dunn
Oct 1, 1994·Diabetes/metabolism Reviews·G H Tomkin, D Owens
Apr 1, 1982·Acta diabetologica latina·D FedeleG Crepaldi
Jul 1, 1980·Acta diabetologica latina·D SommarivaA Fasoli
Apr 1, 1986·Acta diabetologica latina·L BeccariaG Chiumello
Jan 1, 1991·Acta diabetologica latina·A VerrottiG Morgese
Jan 13, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·P H WinocourP N Durrington
Feb 4, 1999·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·F MilliatC Lutton
Aug 1, 1987·Baillière's Clinical Endocrinology and Metabolism·A H Kissebah, G Schectman
Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·B Idzior-WalusUNKNOWN EURODIAB IDDM Complications Study Group
Feb 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·M B MattockUNKNOWN EURODIAB IDDM Complications Study
Sep 13, 1984·The New England Journal of Medicine·J M SosenkoK H Gabbay
Oct 11, 1984·The New England Journal of Medicine·C E WaldenE Strandness
Oct 6, 2012·Southern Medical Journal·Avnish TripathiJeanette M Jerrell
Jul 29, 2000·Australian and New Zealand Journal of Medicine·H M FarouqueI T Meredith
Jan 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·P K MerrinR S Elkeles
Mar 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·P LeeJ Best
Aug 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·D OwensG H Tomkin
Nov 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·J M SosenkoR B Goldberg
Nov 19, 1997·The Journal of Pharmacy and Pharmacology·M C SatiaR K Goyal
Aug 1, 1994·Archives of Disease in Childhood·K AzadK G Alberti
Oct 1, 1991·Postgraduate Medical Journal·P K Merrin, R S Elkeles
Aug 1, 1984·The Journal of Clinical Investigation·D RaumK H Gabbay
Oct 30, 2010·Clinical and Experimental Hypertension : CHE·Enrique HongSantiago Villafaña
Jun 18, 1998·Archives of Physical Medicine and Rehabilitation·P E MosherR B Goldberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.