Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion

Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP
Mohammad AbdollahiMaryam Saadat

Abstract

We examined the effects of subchronic exposure to malathion, an organophosphorous (OP) insecticide, on plasma glucose and hepatic enzymes of glycogenolysis and gluconeogenesis in rats in vivo. Malathion was administered orally at doses of 100, 200 and 400 ppm for 4 weeks. At the end of the specified treatment (18 h fasting after the last dose of malathion), the liver was removed. The activities of glycogen phosphorylase (GP) and phosphoenolpyruvate carboxykinase (PEPCK) were analyzed in the homogenate. Four weeks administration of malathion at doses of 100 ppm, 200 ppm, and 400 ppm increased plasma glucose concentrations by 25% (P < 0.01), 17% (P < 0.01), and 14% (P < 0.01) of control, respectively. Malathion also increased hepatic PEPCK activity by 25% (100 ppm, P < 0.01), 16% (200 ppm, P < 0.01), and 21% (400 ppm, P < 0.01) of control, respectively. In addition, malathion increased hepatic GP by 22% (100 ppm, P < 0.01), 41% (200 ppm, P < 0.01), and 32% (400 ppm, P < 0.01) of controls. We conclude that exposure of rats to malathion as a widely used OP in subchronic exposure, which resembles human exposure, may induce diabetes associated with stimulation of hepatic gluconeogenesis and glycogenolysis in favor of glucose release ...Continue Reading

References

Mar 1, 1975·Metabolism: Clinical and Experimental·J N FainA Arnold
Jan 1, 1990·Journal of Inherited Metabolic Disease·H G Hers
Jul 20, 1990·Biochimica Et Biophysica Acta·B N PatelP N Durrington
Jan 1, 1986·Journal of Toxicology and Environmental Health·D D LiuB Hoskins
Jan 1, 1987·Diabetes/metabolism Reviews·J H Exton
Jan 1, 1987·Journal of Biochemical Toxicology·M A Matin, K Husain
Jun 1, 1983·Journal of Toxicology. Clinical Toxicology·Z ZadikS Levin
May 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G Begum, S Vijayaraghavan
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L RothmanG I Shulman
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·M AbdollahiT Ghanea
Aug 17, 1999·Annual Review of Nutrition·R C NordlieA J Lange
Aug 17, 2000·Current Opinion in Lipidology·M I MacknessB Mackness
Jan 5, 2001·Pharmacology & Toxicology·M C YangD G Le Couteur
Jan 24, 2002·Environmental Toxicology and Chemistry·Sandrine BretaudBenoit Auperin
Aug 21, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohammad AbdollahiKhatereh Zafari
Dec 23, 2003·Human & Experimental Toxicology·Mohammad AbdollahiArezou Bahreini-Moghadam

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Citations

Jul 26, 2012·Environmental Science and Pollution Research International·Seiichi UnoJiro Koyama
Sep 30, 2008·Pakistan Journal of Biological Sciences : PJBS·Goudarz Sadeghi-HashjinShahram Javadi
Feb 5, 2016·Rapid Communications in Mass Spectrometry : RCM·Xiangkun Yang, Michael G Bartlett
Feb 14, 2013·Toxicology and Applied Pharmacology·Sara Mostafalou, Mohammad Abdollahi
Jan 22, 2013·Environmental Toxicology and Pharmacology·Eman E ElsharkawyNeveen A El-Nisr
Aug 17, 2011·Environmental Toxicology and Pharmacology·Mariana AstizCarlos Alberto Marra
Sep 26, 2008·Journal of Hazardous Materials·Mohamed M LasramNajoua Gharbi
Feb 17, 2007·Comptes rendus biologies·Raja RezgNajoua Gharbi
Nov 29, 2015·Pesticide Biochemistry and Physiology·Deepa GandhiSivanesan Saravanadevi
Jan 8, 2008·The Journal of Animal Ecology·Melina CamperoRobby Stoks
Apr 17, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·K Swaminathan
Jul 15, 2015·Environmental Science and Pollution Research International·Imen Flehi-SlimHassen Ben Cheikh
Nov 29, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Xiao-yong ChenXin-mei Liu
Apr 8, 2016·Environmental Science and Pollution Research International·Emiko KokushiSeiichi Uno
Dec 23, 2014·Journal of Diabetes and Metabolic Disorders·Haji BahadarMohammad Abdollahi
Jan 15, 2015·Journal of Environmental Management·Theophilus K UdeigweTarek Kandakji
Aug 14, 2012·Clinical Biochemistry·Nermin RaafatHatem M Salem
Aug 18, 2016·Canadian Journal of Physiology and Pharmacology·Anouar FerianiMohamed Salah Allagui
Nov 28, 2012·Journal of Environmental Management·Zia ChishtiMuhammad Arshad
Oct 21, 2016·Reproductive Toxicology·Jerrold J HeindelFrederick Vom Saal
Aug 3, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Apurva Kumar R Joshi, P S Rajini
Apr 1, 2016·Toxicology and Industrial Health·Veruscka LesoIvo Iavicoli
Jul 6, 2017·Environmental Toxicology·Kamal NiazMohammad Abdollahi
Oct 14, 2011·International Journal of Toxicology·Imen Ayed-BoussemaHassen Bacha

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