Hyperglycemia at admission and during hospital stay are independent risk factors for mortality in high risk cardiac patients admitted to an intensive cardiac care unit

European Heart Journal. Acute Cardiovascular Care
Jonathan A LiptonK Martijn Akkerhuis

Abstract

Hyperglycemia is associated with increased mortality in cardiac patients. However, the predictive value of admission- and average glucose levels in patients admitted to an intensive cardiac care unit (ICCU) has not been described. Observational study of patients admitted to the ICCU of a tertiary medical center in whom glucose levels were measured at and during admission. Over a 19-month period, 1713 patients were included. Mean age was 63±14 years, 1228 (72%) were male, 228 (17%) had known diabetes. Median (interquartile) glucose levels at admission were 7.9 (6.5-10.1) mmol/l; median glucose levels during ICCU admission (873 patients with three or more measurements) were 7.3 (6.7-8.3) mmol/l. Cox regression analysis was performed including the variables age, gender, admission diagnosis, length of stay, prior (cardio)vascular disease and diabetes. A 1 mmol/l increase in admission glucose level (above 9 mmol/l) was associated with a 10% (95% confidence interval (CI): 7 -13%) increased risk for all-cause mortality. A 1 mmol/l higher average glucose level (above 8 mmol/l) was an additional independent predictor of mortality (HR 1.11, 95% CI: 1.03 - 1.20). At 30 days, 16.8% (97/579) of the patients with an admission glucose level i...Continue Reading

References

Feb 1, 1990·Diabetes Care·J P Le FlochL Perlemuter
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
Mar 15, 2002·The American Journal of Medicine·Michael F Oliver
Jun 8, 2002·International Journal of Medical Informatics·Axel JungerGunter Hempelmann
Nov 26, 2002·Journal of the American College of Cardiology·Nazneem N WahabUNKNOWN ICONS Investigators
May 16, 2007·Heart·C WestonUNKNOWN National Audit of Myocardial Infarction Project, National Institute for Clinical Outcomes Research
Dec 1, 2007·Journal of the Royal Society of Medicine·Khairollah AsadollahiGeoffrey Gill
Jan 9, 2008·QJM : Monthly Journal of the Association of Physicians·S PenfoldD Kerr
Mar 26, 2009·The New England Journal of Medicine·Simon FinferJuan J Ronco

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Citations

Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Leigh A Callahan, Gerald S Supinski
Oct 8, 2015·The American Journal of the Medical Sciences·Gagandeep KaurKenneth E Izuora
Dec 18, 2015·International Heart Journal·Ewa UscinskaAgnieszka M Tycinska
Aug 25, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·F AvanziniUNKNOWN GLICINE-SPIDER Collaborative Group
Jun 24, 2015·Critical Care : the Official Journal of the Critical Care Forum·Esther V UijtendaalToine C G Egberts
Jul 6, 2016·International Journal of Cardiology·Lina Badimon, Judit Cubedo
Mar 5, 2015·European Heart Journal. Acute Cardiovascular Care·Fausto AvanziniUNKNOWN Desio Diabetes Diagram (DDD) study group
Jul 2, 2019·Journal of Community Hospital Internal Medicine Perspectives·Patrick McgradeKenneth Nugent
Dec 6, 2017·European Heart Journal. Acute Cardiovascular Care·Chayakrit KrittanawongEdgar Argulian
Nov 22, 2018·Archives of Endocrinology and Metabolism·Denise P MomessoAndre Volschan
Nov 8, 2018·Journal of Diabetes Research·Ferdinando Carlo SassoRaffaele Marfella
Jul 6, 2021·Frontiers in Endocrinology·Cyril P Landstra, Eelco J P de Koning

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS

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