Hyperglycemia at presentation is associated with in hospital mortality in non-diabetic patient with organophosphate poisoning

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Jeong Mi MoonYong Soo Cho

Abstract

This study evaluated whether the initial venous glucose level at presentation is associated with fatality in organophosphate (OP)-poisoned patients without diabetes mellitus (DM) and whether the association between glucose and outcome differs depending on the chemical formulation of the OP ingested. This retrospective observational case series consisted of 184 patients without DM who had a history of OP poisoning. Initial glucose level at presentation, outcome and general clinical data were recorded. The patients were categorized into the following groups according to their glucose level at presentation: group 1 (<140 mg/dl, n = 63), group 2 (140-200 mg/dl, n = 58), group 3 (200-300 mg/dl, n = 41), and group 4 (≥300 mg/dl, n = 22). The most commonly ingested OPs were dichlorvos (n = 33), fenitrothion (n = 25), and ethyl p-nitrophenol thio-benzene phosphonate (EPN) (n = 24). The primary outcome was case fatality. Group 4 had a higher case fatality than groups 1 (p = 0.003) and 2 (p = 0.015), and group 3 had a higher case fatality than group 1 (p = 0.040). Multivariate analysis revealed that age [odds ratio (OR) 1.065, 95% confidence interval (CI) 1.020-1.112, p = 0.001], being in group 3 (OR 6.997, 95% CI 1.063-46.066, p = 0.043...Continue Reading

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Citations

Oct 12, 2018·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Robert M GiffordMichael Eddleston
Dec 16, 2019·International Archives of Occupational and Environmental Health·Martin Rune Hassan HansenVivi Schlünssen
Apr 22, 2020·Environmental Science and Pollution Research International·Saeed SamarghandianTahereh Farkhondeh
Jun 4, 2021·Scientific Reports·Jia-Ruei YuTzung-Hai Yen

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