Jan 1, 1989

Hyperglycemia-conditioned increase in alpha-2-macroglobulin in healthy normal subjects: a phenomenon correlated with deficient antithrombin III activity

Acta Haematologica
A CerielloD Giugliano


Induced hyperglycemia in normal subjects increases alpha 2-macroglobulin (alpha 2M) activity and alpha 2M concentration and reduces antithrombin III (ATIII) activity, while it does not affect ATIII plasma concentration. Hyperglycemia-determined variations in ATIII activity and alpha 2M molecules are correlated in an inverse and parallel fashion. A compensatory role for the increase in alpha 2M in the regulation of the coagulation system may be hypothesized. Moreover, these data provide evidence that hyperglycemia may decrease, directly, the biological function of some proteins and may influence the levels of some risk factors for the development of complications in diabetes.

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Mentioned in this Paper

Alpha 1-Acute Phase Globulin
SERPINC1 wt Allele
Alpha 2-Glucoproteins
Clotting Inhibitors or Anticoagulants; Antithrombin III, Activity
Blood Coagulation
Antithrombin III Measurement
Coagulation Process
A2M gene

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