Hyperglycemia potentiates the slowing of gastric emptying induced by exogenous GLP-1

Diabetes Care
Mark P PlummerAdam M Deane

Abstract

Acute hyperglycemia markedly slows gastric emptying. Exogenous GLP-1 also slows gastric emptying, leading to diminished glycemic excursions. The primary objective was to determine whether hyperglycemia potentiates the slowing of gastric emptying induced by GLP-1 administration. Ten healthy participants were studied on 4 separate days. Blood glucose was clamped at hyperglycemia using an intravenous infusion of 25% dextrose (∼12 mmol/L; hyper) on 2 days, or maintained at euglycemia (∼6 mmol/L; eu) on 2 days, between t = -15 and 240 min. During hyperglycemic and euglycemic days, participants received intravenous GLP-1 (1.2 pmol/kg/min) and placebo in a randomized double-blind fashion. At t = 0 min, subjects ingested 100 g beef mince labeled with 20 MBq technetium-99m-sulfur colloid and 3 g 3-O-methyl-glucose (3-OMG), a marker of glucose absorption. Gastric emptying was measured scintigraphically from t = 0 to 240 min and serum 3-OMG taken at regular intervals from t = 15 to 240 min. The areas under the curve for gastric emptying and 3-OMG were analyzed using one-way repeated-measures ANOVA with Bonferroni-Holm adjusted post hoc tests. Hyperglycemia slowed gastric emptying (eu/placebo vs. hyper/placebo; P < 0.001) as did GLP-1 (eu/...Continue Reading

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Citations

Jul 29, 2015·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Enid E MartinezNilesh M Mehta
Oct 9, 2018·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Adam M DeaneAnton Emmanuel
Mar 15, 2019·Journal of Neurogastroenterology and Motility·Peng DuLeo K Cheng
Feb 8, 2020·Diabetes Care·Kara R Mizokami-StoutUNKNOWN T1D Exchange Clinic Networ k
Nov 8, 2018·Journal of Diabetes Research·Bogdan Mircea MihaiCristina Mihaela Lăcătușu
Oct 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Palash KarAdam M Deane
Nov 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Tejaswini Arunachala MurthyChinmay S Marathe
Jul 29, 2020·Gastroenterology Clinics of North America·Alan H Maurer

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