Hyperglycemia suppresses the regulatory effect of hypoxia-inducible factor-1α in pulmonary Aspergillus fumigatus infection.

Pathogens and Disease
Yao YeWei Wang

Abstract

Aspergillus fumigatus is one of the most common fungal infections involved in the pulmonary diseases. Hypoxia-inducible factor-1α (HIF-1α) is important for antifungal immunity. Diabetes is a risk factor of pulmonary A. fumigatus infection and could affect the expression of HIF-1α. The aim of this investigation was to evaluate the role of HIF-1α in pulmonary A. fumigatus infection in diabetes. In murine model, we found diabetic mice had aggravated pulmonary A. fumigatus infection and declined expression of HIF-1α following pulmonary A. fumigatus infection. And these changes could be corrected by dimethyloxalylglycine (DMOG), the agonist of HIF-1α. In cell experiment, after A. fumigatus stimulation, hyperglycemic state was with a decreased HIF-1α expression and increased NLRP3/IL-1β signal pathway. The percentages of Th1 and Treg cells decreased, while percentages of Th2 and Th17 increased in hyperglycemic group. DMOG suppressed A. fumigatus-stimulated NLRP3 and IL-1β expressions in hyperglycemic group and corrected Th and Treg cells differentiation. These regulatory effects of DMOG could be dampened by activating of NLRP3. These data indicated that hyperglycemia suppressed the regulatory effect of HIF-1α in pulmonary A. fumigatu...Continue Reading

References

Nov 1, 1994·Journal of Medical Microbiology·L A Hall, D W Denning
Apr 9, 1999·Clinical Microbiology Reviews·J P Latgé
Aug 12, 2004·Physiology·Gregg L Semenza
Nov 25, 2004·Diabetes·Sergiu-Bogdan CatrinaLorenz Poellinger
Dec 13, 2005·Nature Reviews. Immunology·Gordon D Brown
May 28, 2008·The Journal of Experimental Medicine·Matthias LochnerGérard Eberl
Dec 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ileana Ruxandra BotusanSergiu-Bogdan Catrina
Dec 18, 2009·Cell Cycle·Hariharan ThangarajahGeoffrey C Gurtner
Aug 17, 2010·Respiratory Physiology & Neurobiology·Bettina SchaibleCormac T Taylor
Jan 17, 2013·Endocrinology·Suheda ErenerTimothy J Kieffer
Feb 15, 2013·Mycoses·Cornelia Lass-FlörlLuigina Romani
Mar 5, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patricia R TaylorEric Pearlman
Nov 5, 2014·Immunity·Asis PalazonRandall S Johnson
Mar 15, 2015·Cell Host & Microbe·Jeffrey Tomalka, Amy G Hise
Apr 17, 2015·Immunological Reviews·Frank L van de VeerdonkMihai G Netea
Aug 25, 2015·Molecular Immunology·Anthony T Phan, Ananda W Goldrath
Sep 4, 2015·Physiology·Nanduri R Prabhakar, Gregg L Semenza
Jul 23, 2016·Journal of Cellular Biochemistry·Afonso Kopczynski de CarvalhoAlexandre Pastoris Muller

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Related Papers

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Richard W Weber
Trends in Microbiology
Natália S WassanoAndré Damasio
© 2021 Meta ULC. All rights reserved