Hyperglycosylated human chorionic gonadotropin as an early predictor of pregnancy outcomes after in vitro fertilization

Fertility and Sterility
Sandy ChuanH Irene Su

Abstract

To determine whether serum hyperglycosylated human chorionic gonadotropin (hhCG) measured as early as 9 days after egg retrieval can predict ongoing pregnancies after in vitro fertilization and fresh embryo transfer (IVF-ET). Cohort Academic assisted reproduction center. Consecutive patients undergoing IVF-ET INTERVENTION(S): Serum hhCG and hCG levels measured 9 (D9) and 16 (D16) days after egg retrieval Ongoing pregnancy beyond 9 weeks of gestation. Ongoing pregnancy (62 of 112 participants) was associated with higher D9 levels of hhCG and hCG. However, hhCG was detectable in all D9 OP samples, while hCG was detectable in only 22%. A D9 hhCG level of >110 pg/mL was 96% specific for an ongoing pregnancy, yielding a positive predictive value of 94%. Compared with the D9 hCG levels, hhCG was more sensitive and had a larger area under the curve (0.87 vs. 0.67, respectively). The diagnostic test characteristics were similar between the D16 hhCG and hCG levels. In patients undergoing assisted reproduction, a test to detect pregnancy early and predict outcomes is highly desirable, and hhCG is detectable in serum 9 days after egg retrieval IVF-ET cycles. In this early assessment, hhCG was superior to traditional hCG and highly predict...Continue Reading

References

Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·E ReshefJ L Luborsky
Oct 1, 1987·The Journal of Clinical Endocrinology and Metabolism·L A Cole
Jan 13, 1999·Prenatal Diagnosis·J F O'ConnorG Kovalevskaya
Sep 21, 2002·Molecular and Cellular Endocrinology·G KovalevskayaJ F O'Connor
Mar 24, 2004·Journal of Assisted Reproduction and Genetics·Francisco CarmonaJuan A Vanrell
Jun 13, 2006·Clinical Biochemistry·Jaime M Sutton-RileyLaurence A Cole
Aug 7, 2007·Fertility and Sterility·Yasushi SasakiLaurence A Cole
Jun 30, 2009·Journal of Reproductive Immunology·Laurence A Cole
Aug 26, 2010·Reproductive Biology and Endocrinology : RB&E·Laurence A Cole

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Citations

Dec 18, 2015·American Journal of Reproductive Immunology : AJRI·Jemma Evans
Aug 12, 2019·American Journal of Obstetrics and Gynecology·Paula C BradyElizabeth S Ginsburg

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