Hypergravity from conception to adult stage: effects on contractile properties and skeletal muscle phenotype

The Journal of Experimental Biology
Cyril BozzoY Mounier

Abstract

This study examined the effects of an elevation of the gravity factor (hypergravity--2 g) on the molecular and functional characteristics of rat soleus and plantaris muscles. Long Evans rats were conceived, born and reared (CBR) continuously in hypergravity conditions until the age of 100 days. Whole muscle morphological parameters, Ca2+ activation characteristics from single skinned fibers, troponin (Tn) subunit and myosin heavy (MHC) and light (MLC) chains isoform compositions were examined in CBR and control muscles from age-paired terrestrial rats. Decreases in body and muscle mass in soleus and plantaris muscles were observed and associated, in the soleus, with a decrease in fiber diameter. The specific force of CBR soleus fibers was increased, and correlated with the elevation of Ca2+ affinity. This was accompanied by slow-to-slower TnC and TnI isoform transitions and a rearrangement in TnT fast isoform content. The MHC transformations of the soleus after hypergravity were associated with the up (down)-regulation of the MHCI (MHCIIa) mRNA isoforms. The MLC2 phosphorylation state remained unchanged in the soleus muscle. The results suggested that the gravity factor could interact with rat muscle development and that hyperg...Continue Reading

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Citations

Jul 13, 2007·European Journal of Applied Physiology·Rita FerreiraJosé Alberto Duarte
Mar 21, 2015·Scientific Reports·Stéphanie GhislinJean-Pol Frippiat
Jul 23, 2013·The European Journal of Neuroscience·Nadjet SerradjMarc Jamon
Sep 21, 2016·Journal of Proteome Research·Ravikumar HosamaniSharmila Bhattacharya
Apr 18, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·B RoelsR Candau

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