Hyperhemolysis Syndrome without Underlying Hematologic Disease

Case Reports in Hematology
Lauren Anne EberlyNathaniel Perryman Collins

Abstract

Introduction. Hyperhemolysis is characterized by a life-threatening hemolytic transfusion reaction, with hemoglobin (Hb) and hematocrit (Hct) dropping markedly lower than before transfusion. This phenomenon, commonly described in sickle cell disease, is a rare occurrence in patients without hemoglobinopathies. Case Report. A 55-year-old male presented to the hospital after a motorcycle crash and received 10 units of cross-matched blood for active bleeding. The patient was blood group O, with a negative antibody screen. Ten days later, he represented complaining of dyspnea and was found to have a hematocrit of 12%. The direct antiglobulin test was positive for anti-immunoglobin G and complement. Indirect antiglobulin test was positive for anti-Jka alloantibodies. The presence of Jka antigen was revealed in one unit of previously transfused blood; patient's RBCs were negative for the Jka antigen. Laboratory data demonstrated findings consistent with DHTR, as well as reticulopenia and elevated ferritin levels. He continued to show signs of active hemolysis, requiring a total of 4 subsequent units of pRBCs. Each transfusion precipitated a drop in Hb and Hct to levels lower than before transfusion; once transfusions were held, the p...Continue Reading

References

Jan 1, 1996·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P MizonJ Goudemand
Apr 1, 1997·Transfusion·L D PetzR M Herron
Nov 14, 1997·Transfusion·G SirchiaP Rebulla
Mar 29, 2001·Transfusion·N WinT C Pearson
May 1, 2001·Transfusion Medicine·J D GraingerR Wynn
Jun 19, 2004·Hematology·Jennifer G Treleaven, Nay Win
Dec 24, 2005·Transfusion·Kamran Darabi, Sunny Dzik
Dec 31, 2009·Asian Journal of Transfusion Science·Lakmali R MorawakageS K Wijewardana
Apr 1, 2009·Expert Review of Hematology·Nay Win
Apr 27, 2013·Journal of Pediatric Hematology/oncology·Elena Aragona, Michael J Kelly
Feb 8, 2014·Transfusion Medicine·M Rogers, G Smith
Jul 6, 2014·Leukemia & Lymphoma·Matthew YanYulia Lin

❮ Previous
Next ❯

Citations

Aug 5, 2017·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·María de Los Ángeles Mejías ManzanoYolanda María Sánchez Torrijos
Feb 15, 2021·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Merline AugustineSangeetha K Nayanar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.