Hyperhomocysteinemia: A Risk Factor for Cognitive Decline in mTBI Patients

Neurology
Suresh KumarAryan Kumar

Abstract

Our quest was to find an answer for "Why are some people able to recover 100% from a concussion/traumatic brain injury while others tend to have prolonged symptoms after their concussion/traumatic brain injury?" The prevalence of hyperhomocysteinemia in general is 5%-7% with increasing evidence showing higher prevalence of HHcy as age increases. The prevalence of vitamin D deficiency was 41.6% in the American population. The prevalence of vitamin B-12 deficiency is at least 40% in the patients of the Americas. With recent data, the prevalence of magnesium deficiency is around 10%-30% of the population. Hyperhomocysteinemia due MTHFR gene mutation B-12, B-6, magnesium, and folic acid deficiency is well established. A retrospective study involving 45 patients was conducted in order to correlate the persistent symptoms concussion head injury/traumatic brain injury and their bio nutraceutical deficiency. This data provides evidence that a patient's Homocysteine levels are significantly linearly related with their MoCA scores (t = -5.837, df = 34, p-value = 1.403e-06, [95% CI: -0.8406114 to -0.4936554]). In the mTBI group, for every 1 umol/L increase in Homocysteine levels, there is a 0.54217 decrease in MoCA scores. mTBI patients t...Continue Reading

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