Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Shintaro NakanoMakoto Suematsu

Abstract

Elevated plasma homocysteine levels are considered an independent risk factor for cardiovascular diseases. Experimental evidence has shown that hydrogen sulfide anion (HS(-)) protects the myocardium from ischemia/reperfusion (IR) injury. Both homocysteine levels and endogenous HS(-) production are mainly regulated by two transsulfuration enzymes, cystathionine β-synthase (CBS) and cystathionine γ-lyase (CTH). We hypothesized that the transsulfuration pathway plays essential roles in the development of cardiac adaptive responses against ischemia, and investigated the roles of homocysteine, HS(-), and transsulfuration enzymes in fasting-induced cardioprotection against IR injury utilizing hyperhomocysteinemic Cbs (-/-) and Cth (-/-) mice. Langendorff-perfused hearts were subjected to 25-min global ischemia, followed by 60-min reperfusion. Two-day fasting ameliorated left ventricular dysfunction after reperfusion via propargylglycine- and glibenclamide-sensitive pathways in wild-type mice but not in Cbs (-/-) or Cth (-/-) mice, although fasting induced cardiac expression of several Nrf2 target antioxidant genes in both wild-type and Cth (-/-) mice. Intraperitoneal administration of sodium hydrosulfide (a HS(-) donor) at 24 h prior...Continue Reading

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·M WatanabeN Maeda
Aug 12, 1999·Free Radical Biology & Medicine·N Hogg
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·Y ToyodaJ D McCully
Oct 19, 2001·Basic Research in Cardiology·R RamasamyS Schaefer
Oct 7, 2004·The Journal of Biological Chemistry·Kazuhiko NamekataHideo Kimura
May 14, 2005·Antioxidants & Redox Signaling·Kimihito FujiiMakoto Suematsu
Aug 17, 2005·Journal of Thrombosis and Haemostasis : JTH·S R Lentz
Nov 9, 2005·Circulation·Ismayil AhmetMark Talan
Sep 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·John W ElrodDavid J Lefer
Oct 17, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Hieronim Jakubowski
Oct 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Ken ShinmuraRoberto Bolli
Feb 20, 2009·European Heart Journal·Marco RanucciRajendra H Mehta
Nov 27, 2009·Antioxidants & Redox Signaling·Mayumi KajimuraMakoto Suematsu
Oct 8, 2011·Circulation Research·Asif K MustafaSolomon H Snyder
Nov 19, 2011·PloS One·Sapna Gupta, Warren D Kruger
Jan 11, 2012·Antioxidants & Redox Signaling·Hideo KimuraYuka Kimura
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Takayuki MorikawaMakoto Suematsu
Feb 7, 2012·Antioxidants & Redox Signaling·Yi-Hong LiuJin-Song Bian
Jul 10, 2012·Nature Chemical Biology·Motohiro NishidaTakaaki Akaike
Jan 9, 2013·Annual Review of Pharmacology and Toxicology·Qiang Ma
Jan 21, 2014·Cell Metabolism·Valter D Longo, Mark P Mattson
Feb 15, 2014·Circulation Research·David J Polhemus, David J Lefer
Mar 19, 2014·Nature Communications·Takehiro YamamotoMakoto Suematsu
Mar 29, 2014·Molecular Nutrition & Food Research·Shotaro KamataIsao Ishii
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tomoaki IdaTakaaki Akaike
Apr 25, 2014·American Journal of Physiology. Renal Physiology·Noriyuki AkahoshiIsao Ishii
Feb 15, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Ken ShinmuraIsao Ishii

❮ Previous
Next ❯

Citations

Oct 23, 2016·Free Radical Biology & Medicine·Yasuaki KabeMakoto Suematsu
Jun 8, 2017·Cell Metabolism·Christopher HineJames R Mitchell
May 12, 2018·British Journal of Pharmacology·Shigemoto FujiiTakaaki Akaike
Dec 31, 2019·Oxidative Medicine and Cellular Longevity·Qin Yang, Guo-Wei He
Oct 29, 2017·Nature Communications·Takaaki AkaikeHozumi Motohashi
Apr 28, 2019·Journal of Molecular Histology·Tingjuan NiHangyuan Guo
Nov 20, 2020·Biochimica Et Biophysica Acta. Bioenergetics·Karim ZuhraAlessandro Giuffrè
Aug 28, 2021·Biomolecules·Ana Karina Aranda-RiveraJosé Pedraza-Chaverri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biosynthetic Transformations

Biosyntheic transformtions are multi-step, enzyme-catalyzed processes where substrates are converted into more complex products in living organisms. Simple compounds are modified, converted into other compounds, or joined together to form macromolecules. Discover the latest research on biosynthetic transformations here.