Hyperhomocysteinemia and low plasma folate as risk factors for central retinal vein occlusion: a case-control study in a Chinese population

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Wei GaoHai-Yan Wang

Abstract

To determine whether hyperhomocysteinemia and low plasma folate are risk factors for central retinal vein occlusion (CRVO) in the Chinese population. A matched case-control study was conducted between July 2004 and May 2005. The study cohort consisted of 64 individuals that had been diagnosed to have CRVO and 64 normal controls (matched for age, gender, hypertension, smoking and drinking habits). None of the cases or controls had a history of diabetes, glaucoma, medication or any other vascular events that might minimize the influence on plasma homocysteine levels. A cross-sectional analysis among the 64 cases was performed to compare the prevalence of hyperhomocysteinemia and low plasma folate among subjects with and without ischemia and subjects with age above 45 and below 45 years. Plasma homocysteine level was measured by means of high-performance liquid chromatography and plasma folate concentration by radioimmunoassay. The CRVO patients had a significantly higher homocysteine level (13.83+/-1.71 micromol/l) than the normal controls (8.05+/-0.58 micromol/l; p=0.003). The plasma folate levels were significantly lower in CRVO patients than in controls (5.62+/-0.39 ng/dl vs 7.23+/-0.60 ng/dl; p=0.032). A 1 micromol/l increase...Continue Reading

References

Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
Mar 24, 1998·Annual Review of Medicine·H RefsumS E Vollset
Mar 8, 2000·Atherosclerosis·A E HakC D Stehouwer
Jul 13, 2000·Acta Ophthalmologica Scandinavica·J LarssonA Hillarp
Apr 6, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sohan Singh HayrehPatricia Podhajsky
Jan 4, 2003·European Journal of Ophthalmology·A M Abu El-AsrarO S Al-Attas
Mar 9, 2004·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Cem YildirimSoner Akpinar

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Citations

Jul 20, 2007·International Ophthalmology·Sasan MoghimiMaryam Maghsoudipour
Jan 2, 2014·Indian Journal of Clinical Biochemistry : IJCB·Kapil D LahiriHarendra N Das
Jun 10, 2011·Clinical Ophthalmology·Rumana N Hussain, Somnath Banerjee
Apr 27, 2013·Indian Journal of Ophthalmology·Fahad Al WadaniSalman Ramzi
Oct 15, 2009·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Gianluca SottilottaVincenzo Trapani Lombardo
Nov 28, 2006·Eye·N GiannopoulosW S T Pollock
Dec 28, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Charles J GlueckKarl Golnik
Sep 16, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Isaac Chun-Hai Fung, Sandy Cairncross
Jul 6, 2010·Current Eye Research·Antonio PinnaCiriaco Carru
Nov 2, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Joseph W SowkaMichael Au
Dec 14, 2019·Scientific Reports·Maria J VieiraJoão P Sousa
May 18, 2021·Klinische Monatsblätter für Augenheilkunde·Dimitrios KazantzisIrini Chatziralli

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