Abstract
A recent "ex-vivo" study showed that nonvalvular atrial fibrillation (NVAF) is associated with enhanced activity of metalloproteinases at the atrial level, and in animal models homocysteine (Hcy) is able to activate metalloproteinases. The aim of this case-control study was to investigate the association of total Hcy plasma levels, vitamin status (folate, vitamin B6, and vitamin B12), and methylenetetrahydrofolate reductase C677T and CBS 844ins68 polymorphisms with NVAF. Furthermore, the role of these variables in the occurrence of ischemic events was investigated. We studied 310 NVAF patients on oral anticoagulant treatment (168 patients with previous ischemic events and 142 without) and 310 controls. Hyperhomocysteinemia (highest quartile) and vitamin B6 deficiency (lowest quartile) were independently associated with NVAF after multivariate analysis (Hcy: odds ratio [OR] 6.40, 95% CI 3.29-12.46; vitamin B6: OR 3.02, 95% CI 1.02-8.95). A significant correlation was found between Hcy levels and left atrial diameter (r = 0.46; P <.001). As shown by multivariate analysis, elevated Hcy levels were an independent risk factor for ischemic complications during NVAF (OR 2.66, 95% CI 1.15-6.20). This study demonstrates a significant as...Continue Reading
References
May 1, 1995·Nature Genetics·P FrosstL P van den Heuvel
Jul 1, 1997·Diabetes Care
Oct 10, 1997·Circulation·R S VasanE J Benjamin
Feb 27, 1999·American Heart Journal·H C DittrichR G Hart
May 21, 1999·Thrombosis Research·B GiustiG Pepe
Aug 7, 1999·Lancet·G J Hankey, J W Eikelboom
Sep 24, 1999·Biochemical and Biophysical Research Communications·A BescondP Charpiot
Jan 12, 2000·Cerebrovascular Diseases·R G HartE Nasco
May 8, 2000·Stroke; a Journal of Cerebral Circulation·J W EikelboomR I Baker
Aug 25, 2000·Journal of Vascular Surgery·T BrunelliG Pepe
Feb 15, 2001·Annals of Internal Medicine·H S Friedman
Mar 7, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·A MurúaL Kordich
Mar 10, 2001·Stroke; a Journal of Cerebral Circulation·V GallaiL Parnetti
Jun 13, 2001·Circulation·S FrisoJ Selhub
Dec 12, 2001·Circulation·M K ChungD R Van Wagoner
Feb 13, 2002·Circulation·Marco ArndtAndreas Goette
Feb 28, 2002·Lancet·Nicholas S PetersVias Markides
Mar 2, 2002·Stroke; a Journal of Cerebral Circulation·Alessandro PezziniAlessandro Padovani
May 17, 2002·The American Journal of Medicine·Arduino A Mangoni, Stephen H D Jackson
Jul 3, 2002·Circulation·Johan E P Waktare
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Matthew J Hunt, Suresh C Tyagi
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
Nov 20, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B Y CingozbayM Dincturk
Nov 26, 2002·BMJ : British Medical Journal·David S WaldJoan K Morris
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Mar 8, 2003·Stroke; a Journal of Cerebral Circulation·Hakan AyOkay Saribas
Apr 12, 2003·The American Journal of Medicine·En-Pei I ChiangRonenn Roubenoff
Apr 19, 2003·Stroke; a Journal of Cerebral Circulation·Gudrun BoysenThomas Truelsen
Citations
Jun 14, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Masayuki ShimanoToyoaki Murohara
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·Ben-Zhi CaiBao-Feng Yang
Feb 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·K C Gorson, A H Ropper
Jan 6, 2010·Circulation·Renate B SchnabelEmelia J Benjamin
Jun 7, 2007·PloS One·Betti GiustiGian Franco Gensini
Feb 11, 2010·International Heart Journal·Franjo NajiMiso Sabovic
Oct 31, 2009·Amino Acids·Andréa Carla CelottoAna Maria de Oliveira
Sep 5, 2012·The Journal of Thoracic and Cardiovascular Surgery·Giuseppe NassoGiuseppe Speziale
Dec 27, 2008·Toxicology·Benzhi CaiBaofeng Yang
Jan 9, 2007·Medical Hypotheses·Felipe P PerezDonald A Jurivich
Nov 3, 2009·Clinical Transplantation·Maurizio AcampaFranco Laghi-Pasini
Mar 7, 2006·Progress in Cardiovascular Diseases·E Kevin Heist, Jeremy N Ruskin
Feb 27, 2016·Journal of Stroke·Maurizio AcampaGiuseppe Martini
Jul 3, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·David R Van Wagoner
Sep 24, 2005·Stroke; a Journal of Cerebral Circulation·Daniela PoliDomenico Prisco
Jul 31, 2020·International Heart Journal·Hao RongJun Pu
Jul 25, 2019·Nutrients·Shuai Yuan, Susanna C Larsson
Jul 30, 2020·Brain Sciences·Dana Simona ChitaSimona Ruxanda Dragan
Nov 22, 2005·Postgraduate Medicine·Indranill Basu Ray, E Kevin Heist
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Michael WainbergNathan D Price
Oct 13, 2010·Molecular and Cellular Biochemistry·Lamia RaafNathalie Janel
Jul 12, 2017·BMC Cardiovascular Disorders·Zhao LiMaria Roselle Abraham
Dec 1, 2020·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Xingang SunLiangrong Zheng
Feb 28, 2020·Biochimie·Brittany BalintRosa-Maria Guéant-Rodriguez
Jun 15, 2021·Frontiers in Genetics·Songzan ChenWenbin Zhang