Hyperhomocysteinemia in acute Plasmodium falciparum malaria: an effect of host-parasite interaction

Clinica Chimica Acta; International Journal of Clinical Chemistry
R ChillemiS Musumeci

Abstract

Plasmodium falciparum utilises the polyamine pathway, essential in proliferation and differentiation, and imposes an oxidative stress on host cell, enhancing the loss of glutathione. Standard hematological parameters were determined in 40 black African subjects with acute P. falciparum malaria, 30 aged 5-24 months, 5 aged 4-10 years and 5 aged 19-35 years. Plasma homocysteine, cysteine, glutathione and cysteinylglycine levels were measured by HPLC method. Twenty-eight healthy black children (15 aged 6-24 months and 13 aged 3-10 years) and 20 healthy black adults (aged 20-40 years) were also included as controls. Plasma homocysteine levels were higher in all subjects with P. falciparum malaria and correlated positively with the disease severity and number of parasites, but negatively with Hb levels and patient ages. Cysteine level was found higher in all patients and markedly higher in 4-10 year old patients. Cysteinylglycine level was found lower particularly in 19-35 year old patients. Glutathione level was significantly lower in all patients. The elevated level of homocysteine during acute P. falciparum infection suggests an imbalance in the folate cycle, which could be a consequence of the reduced availability of NADPH and V...Continue Reading

References

Nov 1, 1995·Antimicrobial Agents and Chemotherapy·J R SufrinC J Bacchi
Mar 1, 1994·Parasite : Journal De La Société Française De Parasitologie·H Ginsburg, H Atamna
Nov 24, 1999·Free Radical Biology & Medicine·L FlohéP Steinert
May 3, 2000·American Journal of Epidemiology·L D Botto, Q Yang
Feb 18, 2003·Journal of the American Dietetic Association·Setareh Torabian EsfahaniMarie A Caudill
Apr 11, 2003·Biochimica Et Biophysica Acta·Ruma BanerjeeShin Taoka
May 20, 2003·Biological Chemistry·Katja BeckerR Heiner Schirmer
Nov 26, 2003·Journal of Theoretical Biology·Michael C ReedCornelia M Ulrich

❮ Previous
Next ❯

Citations

Feb 1, 2012·Molecular Psychiatry·C L Raison, A H Miller
Apr 19, 2008·The Journal of Infectious Diseases·Zacharie TaoufiqDominique Mazier
Oct 7, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Rosa ChillemiSalvatore Musumeci
Jul 3, 2013·Nutrition Reviews·Yves Ingenbleek, Hideo Kimura
Jan 5, 2011·Nutrition Reviews·Abalo Chango, Latifa Abdennebi-Najar
Nov 15, 2011·Tropical Medicine & International Health : TM & IH·Kwami L AwagaSabiba K E Amouzou
Jan 2, 2007·Molecular and Biochemical Parasitology·Rosa M RegueraRafael Balaña-Fouce
Aug 26, 2006·Molecular and Biochemical Parasitology·Zacharie TaoufiqIoannis Vouldoukis
Apr 1, 2014·BMC Research Notes·Masharip AtadzhanovOwen A Ross
May 21, 2016·Transactions of the Royal Society of Tropical Medicine and Hygiene·Darshana MirgalShrimati Shetty
Jul 17, 2018·Parasitology·Divya BeriUtpal Tatu
Apr 24, 2014·The Journal of Biological Chemistry·Shweta ChaubeyUtpal Tatu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Clinical Chemistry and Laboratory Medicine : CCLM
Mariano MalaguarneraSalvatore Musumeci
Clinical Chemistry and Laboratory Medicine : CCLM
Rosa ChillemiSalvatore Musumeci
International Journal for Parasitology
Isabelle M Medana, Gareth D H Turner
© 2021 Meta ULC. All rights reserved