PMID: 16509458Mar 3, 2006Paper

Hyperhomocysteinemia in chronic renal failure patients: relation to tissue factor and platelet aggregation

Clinical Nephrology
O CetinT Ulutin

Abstract

A moderate increase in plasma total homocysteine (t-hcy) is considered to be an independent risk factor for cardiovascular disease (CVD) in general population. One of the mechanisms by which hyperhomocysteinemia contributes to cardiovascular risk has been explained to be the increased thrombotic potential. Elevated t-hcy levels were also reported in chronic renal failure patients because the renal function is a major determinant of serum t-hcy levels. We measured serum hcy and ADP-induced platelet aggregation and plasma tissue factor as a major activator of the coagulation cascade in hemodialysis (HD), peritoneal dialysis (PD) and early stage chronic renal failure (early stage CRF) patients who are not receiving dialysis and compared with those of control. In addition, we also determined serum vitamin B12 and folat levels which are the important factors regulating the metabolism of t-hcy. Hcy levels in all patient groups were significantly higher (HD: 20.42 +/- 1.91 micromol/l, PD: 35.47 +/- 6.30, early stage CRF: 24.39 +/- 3.06) than the normal levels (10.74 +/- 0.74) in spite of standard multivitamin supplementation. The highest t-hcy values were found in peritoneal dialysis patients. Vitamin B12 levels in hemodialysis/perito...Continue Reading

Citations

Jun 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anouk C VedderCarla E M Hollak
Dec 29, 2010·Biochemistry Research International·Amira HamzaouiSilvia Mahjoub
Oct 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jens LutzKlaus Thürmel
Apr 4, 2008·Journal of Clinical Biochemistry and Nutrition·Akiko HirakawaKunihiro Yamagata
Mar 7, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georg SchlieperNikolaus Marx
Jun 26, 2014·Seminars in Dialysis·Moshe ShasharVipul Chitalia
Jan 16, 2015·BMC Nephrology·Kiran P SatheKar-Hui Ng
Jun 6, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Krystyna PawlakDariusz Pawlak
Jan 7, 2017·Journal of the American Society of Nephrology : JASN·Katharina SchuettGeorg Schlieper
Jun 19, 2021·Journal of the American Society of Nephrology : JASN·Nishank JainJohn Arthur

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