Hyperhomocysteinemia in cyclosporine-treated renal transplant recipients

Transplantation
M ArnadottirH Thysell

Abstract

Moderate hyperhomocysteinemia, an independent cardiovascular risk factor, has been reported in renal transplant recipients. In the present study, plasma concentrations of total homocysteine were significantly increased in 120 renal transplant recipients as compared with 60 healthy controls (19.0 +/- 6.9 vs. 11.6 +/- 2.8 mumol/L, P < 0.0001) and as compared with 53 patients without a transplant but with a comparable degree of renal failure (19.0 +/- 6.9 vs. 16.0 4.9 mumol/L, P < 0.01). There was a significant inverse correlation between glomerular filtration rates and plasma homocysteine concentrations in the renal transplant recipients (r = -0.52, P < 0.0001). Groups of renal transplant recipients, with and without cyclosporine, and renal patients without a transplant were studied; these groups were comparable regarding age, sex distribution, glomerular filtration rate, and folate and vitamin B12 concentrations. Renal transplant recipients on cyclosporine had significantly higher plasma homocysteine concentrations than those not on cyclosporine (19.5 +/- 7.6 vs. 16.2 +/- 4.8 mumol/L, P < 0.05), and the patients without a transplant (19.5 +/- 7.6 vs. 16.0 +/- 4.9 mumol/L, P < 0.01). Thus, the hyperhomocysteinemia of renal transp...Continue Reading

References

Jul 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·U B Berg, A B Bohlin
Aug 19, 1992·JAMA : the Journal of the American Medical Association·M J StampferC H Hennekens
Apr 25, 1991·The New England Journal of Medicine·R ClarkeI Graham
Jul 1, 1987·Medicine·B L Kasiske, A J Umen
May 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·L E BrattströmB L Hultberg
Jun 1, 1988·Atherosclerosis·B IsraelssonB L Hultberg
Jun 1, 1969·Scandinavian Journal of Clinical and Laboratory Investigation·J Bröchner-MortensenN Rossing
Mar 1, 1984·European Heart Journal·R GunnarssonC G Groth
Jan 1, 1994·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Z A MassyH Kreis
Feb 2, 1995·The New England Journal of Medicine·J SelhubI H Rosenberg

❮ Previous
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Citations

Aug 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·R PandeyS K Aggarwal
Apr 2, 2004·Rheumatology International·Zeki YesilovaIsmail H Kocar
May 26, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·J V WoodsideI S Young
Apr 1, 1997·Clinical Biochemistry·S E MinerD E Cole
Jul 25, 2003·The Journal of Laboratory and Clinical Medicine·Danila Di GiuseppeFranco Laghi Pasini
Dec 20, 2000·Transplantation Proceedings·S I KimK H Choi
Jan 3, 2001·Transplantation Proceedings·I FonsecaM Pereira
Aug 11, 2001·Transplantation Proceedings·S SavajA J Ghods
May 16, 2002·Transplantation Proceedings·Joanna JuskowaY P Plomiński
Mar 20, 2003·Transplantation Proceedings·B Hultberg, M Arnadottir
Sep 2, 2003·Transplantation Proceedings·C MotaM Pereira
Sep 2, 1999·Advances in Enzyme Regulation·J D HouseJ T Brosnan
Mar 21, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R C CookA P Ignaszewski
Dec 18, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·L PotenaA Branzi
Jul 23, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Francesco ParisiGlauco Catena
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R C CookA P Ignaszewski
Dec 3, 1999·Journal of Internal Medicine·O NygårdP M Ueland
Oct 10, 1998·Kidney International·M ArnadottirE Dimény
Feb 23, 1999·Kidney International·M FödingerG Sunder-Plassmann
Apr 23, 2002·Kidney International·Mihaela C IgnatescuGere Sunder-Plassmann
May 2, 2002·Kidney International. Supplement·Emöke M Dimény
Jun 28, 2002·The New England Journal of Medicine·Claudio Rigatto, Patrick Parfrey
Feb 22, 2002·The New England Journal of Medicine·Manuel PascualA Benedict Cosimi
Feb 15, 1997·Transplantation·M Arnadottir, A L Berg
Mar 9, 2000·Transplantation·B J NankivellR D Allen
Aug 24, 2006·Transplantation·André RoyJean Tchervenkov
Mar 12, 2004·Nephrology·Simon K AustenRob G Fassett
Aug 4, 2009·Biochemistry. Biokhimii︠a︡·A A Boldyrev
Jun 23, 2001·Archives of Disease in Childhood·A J SzabóG S Reusz
Oct 11, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·W HerrmannW Riegel
Oct 4, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Wolfgang Herrmann, Rima Obeid
Jan 1, 2010·International Journal of Nephrology and Renovascular Disease·Vadamalai Vivek, Sunil Bhandari

❮ Previous
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