Hyperhomocysteinemia inhibited cardiac stem cell homing into the peri-infarcted area post myocardial infarction in rats

Experimental and Molecular Pathology
Jie WanGuoping Wang

Abstract

Hyperhomocysteinemia (HHcy) has been reported as an independent risk factor for coronary artery disease; however it is not clear regarding the action of HHcy on the homing of cardiac stem cells (CSCs) to the damaged myocardium and the consequent CSCs-mediated cardiac repair post myocardial infarction. Sprague-Dawley (SD) rats were divided into 4 groups. HHcy was induced in the rats by a 6-week high-methionine diet. Rat heart MI model was developed by left coronary artery ligation. Immunofluorescence was used to examine the CSCs migration in vivo via injecting BrdU-labeled CSCs into AV-groove followed by a coronary ligation. Immunohistochemistry, western blot and ELISA analysis were carried out to detect the expression of stem cell factor (SCF) protein, and RT-PCR was conducted for the expression of SCF mRNA. On day 5 of MI model creation, accumulation of CSCs was significantly increased in the peri-infarcted area by the non-hyperhomocysteinemic rats, which led to an improvement of cardiac function at 3 weeks after MI. however, the accumulation of CSCs was markedly decreased by the hyperhomocysteinemic rats followed with the decline of cardiac function. SCF expression was also significantly decreased in the peri-infarcted area b...Continue Reading

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Citations

May 9, 2014·International Journal of Molecular Medicine·Junli GuoShaojiang Zheng
May 23, 2012·Journal of Cellular and Molecular Medicine·Zhuzhi WenJingfeng Wang
Nov 14, 2015·Journal of Cellular Physiology·Pankaj ChaturvediSuresh C Tyagi
Apr 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Ku-Zaifah NorsidahYusof Kamisah
Aug 3, 2017·Journal of Cellular and Molecular Medicine·Xuan LiFa-Ming Chen
Nov 25, 2017·International Journal of Immunopathology and Pharmacology·Jing-Wen ZhangJian-Zhong Zhang
Oct 17, 2018·Journal of Cardiovascular Translational Research·Zhonghao TaoXin Chen

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