Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis

Metabolism: Clinical and Experimental
Futoshi AnanHironobu Yoshimatsu

Abstract

In patients with chronic renal failure undergoing hemodialysis (HD), the presence of silent cerebral infarction (SCI) is associated with high mortality. Plasma total homocysteine (tHcy), which increases with renal dysfunction, has been flagged as a novel predictor for cerebrovascular events. We tested the hypothesis that the presence of SCI correlates with tHcy in HD patients. Based on brain magnetic resonance imaging findings, 44 patients undergoing HD were divided into a with-SCI group (61+/-9 years [mean+/-SD]; n=24) and a without-SCI group (60+/-8 years, n=20), in whom 24-hour ambulatory blood pressure monitoring was performed. The number of patients with diabetes or hypertension was not different between the 2 groups. We made the following observations: (1) the percentage of smokers was higher in the with-SCI group than in the without-SCI group (P<.05); (2) plasma levels of high-density lipoprotein cholesterol were lower and tHcy was higher in the with-SCI group than in the without-SCI group (P<.05 and P<.0001, respectively); (3) and systolic ambulatory blood pressure and mean heart rate during nighttime were higher in the with-SCI group than in the without-SCI group (P<.05). Multivariate logistic analysis identified hyper...Continue Reading

References

Sep 1, 1988·AJR. American Journal of Roentgenology·B H BraffmanW W Schlaepfer
Aug 1, 1982·Neurology·C M Fisher
Sep 1, 1994·The New England Journal of Medicine·J A Frederick
Mar 1, 1995·Stroke; a Journal of Cerebral Circulation·A ShinkawaM Fujishima
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·J C TsaiM E Lee
Nov 1, 1993·Kidney International·K IsekiK Fukiyama
Nov 1, 1996·Kidney International·K Iseki, K Fukiyama
Oct 28, 1997·Stroke; a Journal of Cerebral Circulation·S KobayashiS Yamaguchi
May 22, 1998·Stroke; a Journal of Cerebral Circulation·G HowardJ F Toole
Jun 19, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M KawamuraT Eto
Sep 6, 2001·Stroke; a Journal of Cerebral Circulation·T MatsuiH Sasaki
Feb 19, 2002·Kidney International·Francesca MallamaciUNKNOWN CREED Investigators
Oct 26, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN Homocysteine Studies Collaboration
Nov 26, 2002·BMJ : British Medical Journal·David S WaldJoan K Morris
Dec 14, 2002·American Journal of Nephrology·Tatsuya NakataniKazunobu Sugimura
Jul 9, 2003·Kidney International·Stephen L SeligerCatherine O Stehman-Breen
Jan 8, 2004·Clinical Chemistry·Helga RefsumJohn M Scott
May 11, 2005·Kidney International·Toshihide NaganumaTatsuya Nakatani

❮ Previous
Next ❯

Citations

Apr 11, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Judith HeinzJutta Dierkes
Jun 22, 2007·Lancet Neurology·Sarah E VermeerPeter J Koudstaal
Aug 7, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Katalin Réka KovácsLászló Csiba
Aug 19, 2015·Nature Reviews. Nephrology·Renhua LuClaudio Ronco
Jun 12, 2012·Clinical Biochemistry·Chia-Chao WuKuo-Cheng Lu
Apr 5, 2008·Orvosi hetilap·Dániel Bereczki
Aug 18, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·H K AggarwalAswvini Bhavikatti
Feb 20, 2019·Nutrients·Irene CapelliGaetano La Manna

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

© 2022 Meta ULC. All rights reserved