Hyperhomocysteinemia is associated with human coronary atherosclerosis through the reduction of the ratio of endothelium-bound to basal extracellular superoxide dismutase

Circulation Journal : Official Journal of the Japanese Circulation Society
Shun-Ichi NiheiTetsuo Adachi

Abstract

Homocysteine is involved in coronary atherosclerosis through oxidative stress, so the present study investigated the association between plasma concentrations of homocysteine and extracellular superoxide dismutase (EC-SOD) in coronary artery disease (CAD). The study group comprised 154 consecutive male patients with suspected CAD who had undergone angiography. Plasma concentrations of homocysteine and EC-SOD, which was determined before (basal) and after heparin therapy, were measured and the difference was designated as endothelium-bound EC-SOD. The EC-SOD ratio (endothelium-bound/basal EC-SOD) was also evaluated as an index of binding capacity. The plasma homocysteine concentration in the stenosis (+) group (n=97, 12.0+/-4.6 micromol/L) was significantly higher than that of the stenosis (-) group (n=57, 10.2+/-3.0 micromol/L, p=0.004). Plasma homocysteine correlated positively with the basal EC-SOD (r=0.377, p<0.001) and negatively with the EC-SOD ratio (r=-0.199, p=0.014). When the group was subdivided according to either homocysteine or the EC-SOD ratio, there were 2 groups with high homocysteine concentration and of these atherosclerosis was reduced in the group with a high EC-SOD ratio. In CAD patients, homocysteine is in...Continue Reading

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Citations

May 23, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Maja ColicMirko Rosic
Jan 19, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Zhenyu QinNeal L Weintraub
Nov 15, 2013·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Yit-Sheung YapYen-Kuang Tai
Jul 29, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Masuo OhashiDonald D Heistad
Jul 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Chin-Hsiao TsengChoon-Khim Chong
Jun 9, 2005·Metabolic Brain Disease·Francieli M StefanelloAngela T S Wyse
Nov 20, 2012·Molecular and Cellular Biochemistry·Sana Venkata Vijaya LakshmiVijay Kumar Kutala
May 8, 2021·Revue des maladies respiratoires·B HauquiertE Deflandre
Mar 8, 2008·Annals of Clinical Biochemistry·Mohsen KerkeniKhira Maaroufi

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