Nov 4, 2005

Hyperhomocysteinemia is associated with volumetric white matter change in patients with small vessel disease

Journal of Neurology
Adrian WongKa Sing Wong


Hyperhomocysteinemia is associated with cerebral small vessel disease (SVD). We examined the relationship between homocysteine and 1) volumetric measure of white matter change (WMC), 2) silent brain infarcts, 3) cerebral atrophy on MRI and 4) cognition on a consecutive cohort of patients with stroke associated with SVD. Fifty-seven patients consecutively admitted to the Acute Stroke Unit in a university hospital due to stroke associated with SVD were recruited and assessed three months after the stroke. Non-fasting homocysteine was obtained. Using MRI, the number of infarcts, volume of WMC and cerebral atrophy were measured. General cognitive functions were assessed using the Mini Mental State Examination and Alzheimer's disease Assessment Scale. Mattis Dementia Rating Scale - Initiation/Perseveration subset was used to assess executive cognitive functions. Hyperhomocysteinemia (> or = 14.88 micromol/L) significantly accounted for the volume of WMC on MRI in a multivariate stepwise regression model (adjusted R(2)=0.058, p <0.05) after adjustment for age and folate level. Patients in the highest quartile of WMC volume had significantly higher levels of homocysteine than those in lowest quartile (p <0.001). No significant relatio...Continue Reading

  • References20
  • Citations32


  • References20
  • Citations32


Mentioned in this Paper

Mini-mental State Examination
Cerebral Atrophy
Cerebrovascular Occlusion
Memory for Designs Test
Transcription Initiation
Incidence Studies
Acute Cerebrovascular Accidents

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Acute Stroke

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