Hyperhomocysteinemia is common in patients with antiphospholipid syndrome and may contribute to expression of major thrombotic events

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
I AviviB Brenner

Abstract

Homocysteine plasma levels were measured by high-performance liquid chromatography in 52 patients with primary antiphospholipid syndrome (APS). Elevated homocysteine concentrations (>or= 15 micromol/l) were found in 16/52 (30.8%) APS patients. Elevated homocysteine levels were found to be associated with an increased risk for a major thromboembolic event (50 versus 16.7%, P = 0.014). Hyperhomocysteinemia is a common finding in APS patients, and may contribute to severity of thrombotic tendency observed in this syndrome.

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Citations

Aug 13, 2003·Kidney International·Didier DuclouxJean-Marc Chalopin
Dec 2, 2011·Internal Medicine·Anastasios MavridisConstantinos Christopoulos
Sep 12, 2003·Current Rheumatology Reports·Bahram Namjou
Nov 6, 2004·Current Rheumatology Reports·Doruk Erkan, Michael D Lockshin
Aug 8, 2009·British Journal of Haematology·Jesús Castro-MarreroJosep Ordi-Ros
Oct 25, 2007·The Australasian Journal of Dermatology·Jemima FisherRodney Hannaford
Jul 31, 2004·Journal of Reproductive Immunology·Richard M LeeRobert M Silver
Oct 4, 2007·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Wei Hsi ChenJia Shou Liu

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Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.