Hypericin-functionalized graphene oxide for enhanced mitochondria-targeting and synergistic anticancer effect

Acta Biomaterialia
Chao HanLingyi Kong

Abstract

Effective targeting of mitochondria has emerged as a beneficial strategy in cancer therapy. However, the development of mitochondria-targeting ligands is difficult because of the low permeability of the mitochondrial double membrane. We found that hypericin (HY), a natural product isolated from Hypericum perforatum L., is an effective mitochondria-targeting ligand. HY-functionalized graphene oxide (GO) loaded with doxorubicin (GO-PEG-SS-HY/DOX) increased the synergistic anticancer efficacy of phototherapy and chemotherapy in the absence of apparent adverse side effects. In vitro and in vivo assays suggested GO-PEG-SS-HY/DOX induced the expression of the key proteins of the mitochondria-mediated apoptosis pathway and caused apoptosis of breast carcinoma cells. In addition, GO vehicle exhibited low toxicity toward normal cells, indicating high safety of functionalized GO preparations in antitumor therapy. Therefore, HY-functionalized GO can be successfully used as a platform technology to target mitochondria in cancer cells and improve the therapeutic efficacy of chemotherapeutic drugs. Induction of mitochondria-mediated apoptosis is a promising approach in cancer therapy. However, mitochondria are difficult to access and permeat...Continue Reading

Citations

Mar 5, 2020·Angewandte Chemie·Si Si LiewShao Q Yao
Apr 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Shi SunXinguang Liu
Dec 12, 2020·Saudi Journal of Biological Sciences·Sugapriya DhanasekaranArif Ahmed Mohammed
May 9, 2021·International Journal of Pharmaceutics·JinLing ZhengHongFei Chen
May 10, 2021·Acta Biomaterialia·Tanveer A Tabish, Roger J Narayan
May 27, 2021·Photodiagnosis and Photodynamic Therapy·Gislaine Patricia de AndradeManoel João Batista Castello Girão
Jun 25, 2021·International Journal of Nanomedicine·Yongjia HuangJingqing Zhang
Jul 17, 2021·Journal of Nanobiotechnology·Guangman CuiGuangyu Yao
Jan 19, 2021·ACS Biomaterials Science & Engineering·Zahra Mohammadpour, Keivan Majidzadeh-A

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