Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in Aluminum chloride-induced Alzheimer's disease rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Zheng CaoYanfei Li

Abstract

Alzheimer's disease (AD) is a progressive and ultimately fatal neurodegenerative diseases. Aluminum, a neurotoxic metal, is considered as the pathological hallmark and contributing factor of AD. Hypericum perforatum extract (HPE) is a neuroprotective agent that can prevent neurodegenerative pathologies through antioxidants, anti-inflammatory and regulating neurotransmitter release in animal model of neuropathy. The present study aimed to identify the potential neuroprotective of HPE on AlCl3-induced AD rats. Rats were treated with AlCl3for 90days to induce behavioral, biochemical, and neurochemical similar to AD. From 31thday, the rats were treated with HPE for 60days. Our results showed HPE improved cognitive function in AlCl3-induced AD rats, and attenuated AlCl3-induced increase in acetylcholinesterase activity and glutamic acid level as well as decreased in noradrenaline and dopamine level. In addition, HPE reversed AlCl3-induced hippocampal pathology including amyloid-beta (Aβ) accumulation (elevated Aβ42 level and amyloid plaques), oxidative stress (increased reactive oxygen species level and thiobarbituric acid reactive substances level, decreased glutathione level and superoxide dismutase activity) and neuroinflammatory...Continue Reading

Citations

Sep 27, 2019·Mini Reviews in Medicinal Chemistry·Mariangela MarrelliFilomena Conforti
Aug 29, 2019·Journal of Histotechnology·Hesham N Mustafa
May 25, 2020·Plant Foods for Human Nutrition·Nebojša KladarBiljana Božin
Feb 11, 2021·Nutrients·Piotr LondzinJoanna Folwarczna
Jul 9, 2021·Environmental Science and Pollution Research International·Hend M HussienSamar R Saleh
Aug 7, 2021·Saudi Journal of Biological Sciences·Xiao ChenPalanisamy Arulselvan
Aug 22, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Gasem Mohammad Abu-Taweel, Mohsen Ghaleb Al-Mutary
Oct 7, 2021·Critical Reviews in Food Science and Nutrition·Zhijun YangHui-Lian Zhu
Dec 30, 2021·Natural Product Research·Angelo FumiaAlessio Alesci

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