Hypericum sampsonii induces apoptosis and nuclear export of retinoid X receptor-alpha

Carcinogenesis
Jin-Zhang ZengXiao-kun Zhang

Abstract

Natural products derived from plants provide a rich source for development of new anticancer drugs. Recent studies suggest that modulation of subcellular localization of retinoid X receptor-alpha (RXRalpha) represents a potential approach for inducing cancer cell apoptosis. In this study, we screened a herbal library for inducing translocation of RXRalpha from the nucleus to the cytoplasm. Our results revealed that the extract of Hypericum sampsonii, a member of the genus Hypericum, had remarkable effect on RXRalpha subcellular localization in various cancer cells. Treatment of NIH-H460 human lung cancer cells with H. sampsonii extract resulted in relocalization of RXRalpha from the nucleus to the cytoplasm. Cytoplasmic RXRalpha induced by H. sampsonii was associated with mitochondria, accompanied with cytochrome c release and apoptosis. H. sampsonii extract effectively inhibited the growth of various cancer cell lines, including NIH-H460 lung cancer, MGC-803 stomach cancer and SMMC7721 liver cancer cells. The growth inhibitory effect of H. sampsonii extract depended on levels of RXRalpha, as it failed to inhibit the growth of CV-1 cells lacking detectable RXRalpha, whereas transfection of RXRalpha into CV-1 cells restored its ...Continue Reading

Citations

Dec 8, 2006·Expert Opinion on Therapeutic Targets·Xiao-kun Zhang
Dec 1, 2015·Regulatory Toxicology and Pharmacology : RTP·Mehmet SarimahmutMustafa Zafer Özel
Nov 17, 2015·Iranian Red Crescent Medical Journal·Maryam Hamzeloo-MoghadamMaryam Malekmohammadi
Aug 1, 2015·Endocrine-related Cancer·Erik HedrickStephen Safe
Aug 11, 2018·Cellular & Molecular Biology Letters·Liqun ChenYiyi Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.