Hyperinsulinemia and left ventricular geometry in a work-site population in Japan

Hypertension
Y OhyaM Fujishima

Abstract

The present study was designed to test whether hyperglycemia or hyperinsulinemia influences left ventricular mass and geometry. An echocardiogram and 75-g oral glucose tolerance test were performed in 210 normotensive and 180 mildly to moderately hypertensive male workers in a bus company who were free from cardiac diseases and were not taking medication for hypertension and diabetes mellitus. When we divided subjects into four groups according to the left ventricular geometric pattern using left ventricular mass index of 110 g/m2 and relative wall thickness (ratio of 2 x posterior wall thickness to end-diastolic left ventricular diameter) of 0.44, body mass index and systolic blood pressure were higher in those with concentric hypertrophy and eccentric hypertrophy. In addition, hemoglobin A(Ic) level and the sum of fasting and 2-hour postload serum glucose levels were higher in subjects with concentric hypertrophy. In subjects without diabetes mellitus (n=336), 2-hour postload serum insulin level and the sum of fasting and 2-hour postload serum insulin levels tended to be higher in those with concentric hypertrophy and concentric remodeling. In multiple regression analysis, the sum of glucose levels (or hemoglobin A(Ic) level)...Continue Reading

References

Oct 1, 1992·The New England Journal of Medicine·E D FrohlichB Massie
May 1, 1992·Archives of Internal Medicine·E GrossmanT Rosenthal
Jun 1, 1992·Journal of the American College of Cardiology·A GanauJ H Laragh
Jan 1, 1990·Journal of Cardiovascular Pharmacology·E FerranniniM P Stern
Mar 14, 1991·The New England Journal of Medicine·M F SaadB V Howard
Sep 1, 1985·Pediatric Research·D J Hill, R D Milner
Mar 1, 1989·American Journal of Hypertension·L Landsberg, D R Krieger
Oct 1, 1989·Hypertension·A P RocchiniM Gregory
Oct 1, 1988·Journal of the American College of Cardiology·I W HammondJ H Laragh
Dec 1, 1994·American Journal of Hypertension·N Hara-NakamuraK Hiwada
Mar 15, 1995·Journal of the American College of Cardiology·H M KrumholzD Levy

❮ Previous
Next ❯

Citations

Jul 30, 1999·The American Journal of Cardiology·P RheederD E Grobbee
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Anne LumiahoMarkku Laakso
Mar 27, 2009·Nature Reviews. Nephrology·Tevfik Ecder, Robert W Schrier
Feb 22, 2011·American Journal of Nephrology·Kentaro NakaiShinichi Nishi
Jun 21, 2005·Cardiovascular Ultrasound·Murilo FoppaLuis E P Rohde
Jul 20, 2002·Journal of Hypertension·Stefan SchäferBodo E Strauer
Jun 24, 2008·Expert Review of Cardiovascular Therapy·Stephen Fava
May 3, 2001·Blood Pressure·J SundströmH Lithell
Apr 12, 2003·Obesity Research·Gianluca IacobellisFrida Leonetti
Jun 11, 2002·Obesity Research·Lelio MorriconeFrancesco Caviezel
Aug 16, 2002·Obesity Research·Gianluca IacobellisFrida Leonetti
Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·R A PhillipsS Shimabukuro
Nov 30, 2000·Upsala Journal of Medical Sciences·H LithellR Reneland
Apr 18, 2017·Journal of the American Veterinary Medical Association·Natalie HeliczerCristobal Navas de Solis
Mar 1, 2003·Clinical Endocrinology·Olga VaccaroUNKNOWN Gubbio Study Research Group
Jan 19, 2021·European Journal of Pediatrics·Panjarat SowithayasakulHermann L Müller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.