Hyperinsulinemia as an independent risk factor for ischemic heart disease

The New England Journal of Medicine
J P DesprésP J Lupien

Abstract

Prospective studies suggest that hyperinsulinemia may be an important risk factor for ischemic heart disease. However, it has not been determined whether plasma insulin levels are independently related to ischemic heart disease after adjustment for other risk factors, including plasma lipoprotein levels. In 1985 we collected blood samples from 2103 men from suburbs of Quebec City, Canada, who were 45 to 76 years of age and who did not have ischemic heart disease. A first ischemic event (angina pectoris, acute myocardial infarction or death from coronary heart disease) occurred in 114 men (case patients) between 1985 and 1990. Each case patient was matched for age, body-mass index, smoking habits, and alcohol consumption with a control selected from among the 1989 men who remained free of ischemic heart disease during follow-up. After excluding men with diabetes, we compared fasting plasma insulin and lipoprotein concentrations at base line in 91 case patients and 105 controls. Fasting insulin concentrations at base line were 18 percent higher in the case patients than in the controls (P<0.001). Logistic-regression analysis showed that the insulin concentration remained associated with ischemic heart disease (odds ratio for isch...Continue Reading

References

Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P CasassusE Eschwège
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E L Bierman
Jul 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Mar 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J P DesprésC Bouchard
Nov 28, 1986·JAMA : the Journal of the American Medical Association·W P CastelliW B Kannel
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·C B Laurell
Sep 1, 1983·American Journal of Epidemiology·T J OrchardA L Drash
Jun 1, 1984·International Journal of Epidemiology·M G Marmot
Jul 1, 1984·American Heart Journal·R F GillumT E Kottke
Jul 1, 1994·Baillière's Clinical Endocrinology and Metabolism·J P Després
Sep 1, 1995·Diabetes Care·D L WingardA Ferrara

❮ Previous
Next ❯

Citations

Aug 10, 1999·Diabetes/metabolism Research and Reviews·H KeenM Laakso
May 18, 1999·Clinical Cardiology·A R AssaliM Fainaru
Mar 10, 2001·Diabetes/metabolism Research and Reviews·M BarbieriG Paolisso
Mar 11, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Ikuo YokoyamaRyozo Nagai
Mar 19, 2008·Cardiovascular Drugs and Therapy·Paresh DandonaPriya Mohanty
Apr 11, 2009·Sleep & Breathing = Schlaf & Atmung·Georgia TrakadaDemosthenes Bouros
Nov 5, 2009·Journal of General Internal Medicine·Philip J SaylorMatthew R Smith
Apr 5, 2002·Current Atherosclerosis Reports·Braxton D Mitchell, Ikhide G Imumorin
Oct 4, 2002·Current Atherosclerosis Reports·Paul Poirier, Robert H Eckel
Feb 3, 2005·Current Atherosclerosis Reports·Brandy PanuntiVivian Fonseca
Oct 16, 2002·Current Cardiology Reports·Gerald R CooperAnd Parvin P Waymack
Mar 20, 2003·Current Diabetes Reports·C DesouzaV Fonseca
Mar 20, 2003·Current Diabetes Reports·Daniel KramerJorge Plutzky
Mar 20, 2003·Current Diabetes Reports·James B Meigs
Sep 17, 2003·Current Diabetes Reports·Afshin Sasali, Jack L Leahy
May 11, 2004·Current Diabetes Reports·Mandeep Bajaj, Mary Ann Banerji
Mar 14, 2007·Current Diabetes Reports·Richard E Pratley
Jan 29, 2008·Current Heart Failure Reports·Gabriele FragassoAlberto Margonato
Sep 12, 2000·Current Hypertension Reports·K M Sowers, J R Sowers
Jul 11, 2012·Biological Trace Element Research·Ju-Hye Chung, Keun-Sang Yum
Jan 1, 2003·Comprehensive Therapy·Biswanath P GoudaVivian A Fonseca
Jun 29, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mario SénéchalRichard Dorent
Jun 1, 2005·International Journal of Cardiology·Vincent BatailleJean Ferrières
Jun 3, 2005·Metabolism: Clinical and Experimental·John A CharlesworthPhilip W Peake
Nov 19, 2003·Pathologie-biologie·Tamas FulopNadine Douziech
Feb 13, 2004·Progress in Cardiovascular Diseases·Suzanne R Steinbaum
May 18, 2001·The American Journal of Cardiology·H N Ginsberg
Jul 18, 2003·The American Journal of Cardiology·Cranford L Scott
Sep 6, 2003·The American Journal of Cardiology·Vivian A Fonseca

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.