PMID: 6990170Apr 1, 1980Paper

Hyperinsulinemia in fructose-induced hypertriglyceridemia in the rat

Metabolism: Clinical and Experimental
J SlederG M Reaven

Abstract

Rats were fed diets containing (as percent of calories) 66% glucose or fructose, 22% casein, and 12% lard, for 1 wk. The effects of these diets on plasma triglyceride, glucose, and insulin concentrations were compared to those of control rats eating regular rat chow. Plasma triglyceride levels increased from a mean (+/- SE) control level of 85 +/- 7 to 142 +/- 9 (p less than 0.001) and 380 +/- 38 (p less than 0.001) mg/dl in dextrose- and fructose-fed rats, respectively. Plasma insulin concentrations demonstrated a similar increase, rising from a mean (+/- SE) control value of 29 +/- 4 microunits/ml to 55 +/- 10 microunits/ml in dextrose-fed rats and 85 +/- 12 microunits/ml in rats eating the fructose diet. Plasma glucose concentrations of the three groups were comparable. These results indicate that fructose-induced hypertriglyceridemia is associated with significant hyperinsulinemia.

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Citations

Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·S W RizkallaM Apfelbaum
Aug 22, 1987·Lancet·G M Reaven, B B Hoffman
Jan 6, 2006·The Journal of Antibiotics·Masamichi InamiSeitaro Mutoh
Jul 28, 2011·Natural Product Research·Mahalaxmi MohanAmol Shinde
Jan 31, 2013·Metabolic Syndrome and Related Disorders·Kristy OsgoodMarie Thearle
Jan 20, 2009·Endocrine Reviews·Richard J JohnsonTakahiko Nakagawa
Jul 28, 2012·The Journal of Endocrinology·María Sol KruseHéctor Coirini
Aug 18, 2009·Journal of Ethnopharmacology·Mahalaxmi MohanSanjay Kasture
Oct 1, 1980·Metabolism: Clinical and Experimental·I ZavaroniG M Reaven
Feb 3, 2015·Mayo Clinic Proceedings·James J DiNicolantonioSean C Lucan
Aug 1, 1996·The Journal of Laboratory and Clinical Medicine·S E Kasim-KarakasM N Goodman
Mar 5, 2002·Diabetes, Obesity & Metabolism·P Anurag, C V Anuradha
Sep 24, 2011·The Journal of Nutrition·Takuya MoriTakatoshi Murase
Nov 4, 2000·The American Journal of Clinical Nutrition·J P BantleA Georgopoulos
Sep 25, 2009·The Journal of Nutrition·Takahiro KawasakiToshikazu Yamanouchi
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Yoshio NagaiAtsunori Kashiwagi
Jun 14, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Olga P Romanko, David W Stepp
Jul 22, 2010·Pharmaceutical Biology·Sandip GodseSanjay Kasture
Feb 9, 2018·The Journal of Toxicological Sciences·Kaoru ToyodaShoichiro Sugai
Dec 8, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Wolfgang Kopp
May 1, 1992·Metabolism: Clinical and Experimental·D N Brindley
Nov 1, 1982·Metabolism: Clinical and Experimental·I ZavaroniG M Reaven
May 1, 1981·Metabolism: Clinical and Experimental·I ZavaroniG M Reaven
Jun 1, 1982·Metabolism: Clinical and Experimental·T A TobeyG M Reaven
Jun 15, 1984·Biochemical and Biophysical Research Communications·R L DrakeC G Mucenski
Oct 8, 2021·Cell Metabolism·Mark A Herman, Morris J Birnbaum

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